2025
Using TCR-CAR dual signaling for precise cancer targeting
Shahbazy M, Leo I, Faridi P, Caron E. Using TCR-CAR dual signaling for precise cancer targeting. Trends In Immunology 2025, 46: 435-437. PMID: 40368698, DOI: 10.1016/j.it.2025.04.007.Commentaries, Editorials and Letters
2024
The Spectrum of CAR Cellular Effectors: Modes of Action in Anti-Tumor Immunity
Nguyen N, Müller R, Briukhovetska D, Weber J, Feucht J, Künkele A, Hudecek M, Kobold S. The Spectrum of CAR Cellular Effectors: Modes of Action in Anti-Tumor Immunity. Cancers 2024, 16: 2608. PMID: 39061247, PMCID: PMC11274444, DOI: 10.3390/cancers16142608.Peer-Reviewed Original ResearchCAR-T cellsLimitations of CAR-T cellsChimeric antigen receptor T cellsBiology of solid tumorsAdoptive cell therapyAnti-tumor immunityCo-stimulatory domainTransgenic cytokinesHLA incompatibilityMode of actionNK cellsHLA compatibilitySwitch receptorsDendritic cellsTumor microenvironmentHematologic neoplasiaT cellsHematological tumorsSolid tumorsImmune cellsAntigen presentationCell therapyCAR activationCellular vehiclesResponse rate
2020
Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)
Dong R, Libby KA, Blaeschke F, Fuchs W, Marson A, Vale RD, Su X. Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR). The EMBO Journal 2020, 39: embj2020104730. PMID: 32643825, PMCID: PMC7429742, DOI: 10.15252/embj.2020104730.Peer-Reviewed Original ResearchConceptsCentral supramolecular activation clusterEssential scaffold proteinT cell receptorSupramolecular activation clusterImmunological synapse formationAntigen receptorActin remodelingScaffold proteinMicrocluster formationDownstream signalingTCR signalingT cell activationSynapse formationCancer cellsSpecific cancer cellsCell receptorSignalingCAR activationT cellsCell activationCellsCAR-T cell activationNative T cellsPathwayActivation clusters
2016
Cytochrome P450 enzymes involved in the primary metabolism of the novel constitutive androstane receptor inhibitor, CINPA1
Cherian M, Yang L, Chai S, Lin W, Chen T. Cytochrome P450 enzymes involved in the primary metabolism of the novel constitutive androstane receptor inhibitor, CINPA1. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.712.8.Peer-Reviewed Original ResearchPregnane X receptorCases of neuroblastomaMultidrug resistanceCAR activationCancer cellsChemo-resistant cancer cellsChemoresistant cancer cellsCytochrome P450 enzymesAttenuate multidrug resistancePharmacokinetic propertiesActivation of pregnane X receptorActivate pregnane X receptorMetabolite 2Reduced therapeutic effectMetabolites 1PXR inhibitorsStructure activity relationship studiesHuman liver microsomesIn vitro enzyme assaysSmall moleculesActivity relationship studiesChemotherapeutic agentsRecruitment of coactivatorsSmall molecule inhibitorsExpression of metabolic genes
2009
The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells
Mamillapalli R, Wysolmerski J. The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells. Journal Of Endocrinology 2009, 204: 287-297. PMID: 20032198, PMCID: PMC3777408, DOI: 10.1677/joe-09-0183.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsACTH secretionCAMP productionProtein-coupled receptorsDifferent G proteinsCaR couplesAtT-20 cellsHormone secretionExtracellular calciumSystemic calcium homeostasisBiological functionsG proteinsBreast cancer cellsCell typesCalcium-sensing receptorCell growthReceptors coupleMalignant breast cellsCancer cellsKidney cellsBreast cellsCAR activationPituitary corticotrophsCalcium homeostasisAnterior pituitary
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