Cytochrome P450 enzymes involved in the primary metabolism of the novel constitutive androstane receptor inhibitor, CINPA1
Cherian M, Yang L, Chai S, Lin W, Chen T. Cytochrome P450 enzymes involved in the primary metabolism of the novel constitutive androstane receptor inhibitor, CINPA1. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.712.8.Peer-Reviewed Original ResearchPregnane X receptorCases of neuroblastomaMultidrug resistanceCAR activationCancer cellsChemo-resistant cancer cellsChemoresistant cancer cellsCytochrome P450 enzymesAttenuate multidrug resistancePharmacokinetic propertiesActivation of pregnane X receptorActivate pregnane X receptorMetabolite 2Reduced therapeutic effectMetabolites 1PXR inhibitorsStructure activity relationship studiesHuman liver microsomesIn vitro enzyme assaysSmall moleculesActivity relationship studiesChemotherapeutic agentsRecruitment of coactivatorsSmall molecule inhibitorsExpression of metabolic genes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply