2023
Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1
Vish K, Stiegler A, Boggon T. Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1. Journal Of Biological Chemistry 2023, 299: 105098. PMID: 37507023, PMCID: PMC10470053, DOI: 10.1016/j.jbc.2023.105098.Peer-Reviewed Original ResearchConceptsSH2 domainSpatial-temporal regulationDual SH2 domainsProper vascular developmentKey binding partnerProtein familySH2 interactionsBinding partnerHuman proteinsDistinct binding interactionsWeakened affinityVascular developmentRasGAPConformational differencesP190RhoGAPSmall-angle X-ray scatteringBindingBinding interactionsAffinity measurementsEphB4DomainGTPaseDok1X-ray scatteringProtein
2009
Separating genetic and hemodynamic defects in neuropilin 1
Jones E, Yuan L, Breant C, Watts R, Eichmann A. Separating genetic and hemodynamic defects in neuropilin 1. The FASEB Journal 2009, 23: 311.1-311.1. DOI: 10.1096/fasebj.23.1_supplement.311.1.Peer-Reviewed Original ResearchVascular developmentProper vascular developmentYolk sac blood vesselsGenetic defectsMutant embryosBiochemical signalingYolk sac arteriesCardiovascular developmentMouse embryo cultureEmbryo growthBlood flowPhysiological functionsHemodynamic defectsVascular defectsVascular formationEmbryo cultureBiological senseNeuropilin-1Proper blood flowPhysical forces
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