2021
Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatients
1986
Intrabiliary glutathione hydrolysis. A source of glutamate in bile.
Ballatori N, Jacob R, Boyer J. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. Journal Of Biological Chemistry 1986, 261: 7860-7865. PMID: 2872220, DOI: 10.1016/s0021-9258(19)57482-8.Peer-Reviewed Original ResearchConceptsGamma-glutamyl transferase activityBiliary excretionRat bileRetrograde intrabiliary infusionAT-125Normal male Sprague-DawleyAdministration of phenolMale Sprague-DawleyNormal rat bileDihydro-5-isoxazoleacetic acidSource of glutamateIntrabiliary infusionRate of excretionDibromphthalein disulfonateBranched chain amino acids valineBiliary treeSprague-DawleyDiethyl maleateBileExcretionTransferase activityGSH secretionLiver cellsMarked decreaseExcretion of glutamate
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