2024
Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis
Ardanaz C, de la Cruz A, Minhas P, Hernández-Martín N, Pozo M, Valdecantos M, Valverde Á, Villa-Valverde P, Elizalde-Horcada M, Puerta E, Ramírez M, Ortega J, Urbiola A, Ederra C, Ariz M, Ortiz-de-Solórzano C, Fernández-Irigoyen J, Santamaría E, Karsenty G, Brüning J, Solas M. Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Science Advances 2024, 10: eadp1115. PMID: 39423276, PMCID: PMC11488540, DOI: 10.1126/sciadv.adp1115.Peer-Reviewed Original ResearchConceptsPeripheral glucose homeostasisBrain glucose metabolismGlucose metabolismAstrocytic glucose transporterGlucose homeostasisPeripheral glucose metabolismSystemic glucose metabolismATP releasePurinergic signalingBlood-borne glucoseBrain metabolismAstrocytesBrain energeticsInsulin signalingCognitive functionGlucose transportBrain functionMiceBrainGLUT1MetabolismHomeostasisObesityA Convolutional Neural Network Approach to Personalized Neuropil Density Prediction
Chang B, Akif A, Onofrey J, Hyder F. A Convolutional Neural Network Approach to Personalized Neuropil Density Prediction. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/4846.Peer-Reviewed Original ResearchConvolutional neural networkSuccess of machine learning methodsConvolutional neural network approachCell countNeural network approachMachine learning methodsNeural cell countNeural networkLearning methodsMetabolic imagingMulti-modal MRINetwork approachSynaptic densityPatient-specificBrain energeticsQuantify electrical activityNeural cellsEnergy budgetDensity predictionElectrical activity
2013
Increased Brain Lactate Concentrations Without Increased Lactate Oxidation During Hypoglycemia in Type 1 Diabetic Individuals
De Feyter HM, Mason GF, Shulman GI, Rothman DL, Petersen KF. Increased Brain Lactate Concentrations Without Increased Lactate Oxidation During Hypoglycemia in Type 1 Diabetic Individuals. Diabetes 2013, 62: 3075-3080. PMID: 23715622, PMCID: PMC3749358, DOI: 10.2337/db13-0313.Peer-Reviewed Original ResearchConceptsBrain lactate concentrationBlood-brain barrierHypoglycemia unawarenessLactate concentrationT1D subjectsControl subjectsType 1 diabetic subjectsType 1 diabetic individualsBlood-borne lactateNondiabetic control subjectsPlasma lactate concentrationMonocarboxylic acid transportDiabetic subjectsHypoglycemic clampT1D patientsDiabetic individualsBrain metabolismBrain fuelBrain glutamateBrain energeticsHypoglycemiaPatientsMetabolic adaptationAcid transportSubjects
2006
Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes. Diabetes 2006, 55: 929-934. PMID: 16567513, PMCID: PMC2995526, DOI: 10.2337/diabetes.55.04.06.db05-1325.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic subjectsControl subjectsType 1 diabetic subjectsInsulin-induced hypoglycemiaNondiabetic control subjectsMonocarboxylic acid transportBrain utilizationSimilar twofold increaseBrain energeticsHypoglycemiaType 1DiabetesOxidative metabolismNonglucose substratesBrainMetabolic substratesUpregulationPatientsAcid transportTwofold increaseSubjectsMagnetic resonance spectroscopyLactateMetabolism
1998
Evaluation of 31P metabolite differences in human cerebral gray and white matter
Mason G, Chu W, Vaughan J, Ponder S, Twieg D, Adams D, Hetherington H. Evaluation of 31P metabolite differences in human cerebral gray and white matter. Magnetic Resonance In Medicine 1998, 39: 346-353. PMID: 9498589, DOI: 10.1002/mrm.1910390303.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAdultAlgorithmsBrainBrain DiseasesEnergy MetabolismEvaluation Studies as TopicFemaleFourier AnalysisHumansHydrogen-Ion ConcentrationImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalePhosphatesPhosphocreatinePhosphorusPhosphorus IsotopesRegression Analysis
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