2025
Do the effects of interventions aimed at the prevention of childhood obesity reduce inequities? A re-analysis of randomized trial data from two Cochrane reviews
Palmer J, Davies A, Spiga F, Heitmann B, Jago R, Summerbell C, Higgins J, Group T, Astrup A, Filho V, Benden M, Boddy L, Bogart L, Brown B, Carlin A, Carrascosa D, Chai L, Drummy C, Duncan S, Ebbeling C, Martos E, Fairclough S, Fulkerson J, Gentile D, Gruber M, Grydeland M, Ha A, Mourad C, Gilstad-Hayden K, Hill D, Hoor G, Hurley K, Hurst A, Hwalla N, Ickovics J, Jolly K, Kain J, Kobel S, Kovacs V, Kriemler S, Kuroko S, Lana A, Levy T, Sánchez-López M, Lubans D, Lynch B, Madsen K, Marcus C, Humarán M, Morales-Ruan C, Morgan P, Müller I, Newton R, Nicholl A, O'Connor T, Pate R, Peña S, Robbins L, Puder J, Robinson T, Rosário R, Rosenkranz R, Sacheck J, Salmon J, Seguin-Fowler R, Sherwood N, Takacs H, Taylor R, Wang H, Wang H, Whittemore R, Wilksch S, Yin Z, Zhou Z, Breheny K, Caldwell D, Dawson S, Gao Y, Hillier-Brown F, Hodder R, Larsen S, Moore T, Nobles J, Phillips S, Savović J, Thorsteinsdottir F, Tomlinson E, Wolfenden L. Do the effects of interventions aimed at the prevention of childhood obesity reduce inequities? A re-analysis of randomized trial data from two Cochrane reviews. EClinicalMedicine 2025, 81: 103130. PMID: 40115176, PMCID: PMC11925530, DOI: 10.1016/j.eclinm.2025.103130.Peer-Reviewed Original ResearchNational Institute for Health and Care ResearchEffectiveness of interventionsPhysical activityCochrane reviewFactors associated with inequalityPrevent childhood obesityAged 5People aged 5Public healthSocio-economic statusBoys aged 5Health inequalitiesHealthy eatingYounger age groupsStandardized BMICare researchChildhood obesityIntervention effectsRandomized trial dataBMI effectsPrevent obesityMeta-analysesBaseline measurementsYear oldsBMIRisk factors affecting polygenic score performance across diverse cohorts
Hui D, Dudek S, Kiryluk K, Walunas T, Kullo I, Wei W, Tiwari H, Peterson J, Chung W, Davis B, Khan A, Kottyan L, Limdi N, Feng Q, Puckelwartz M, Weng C, Smith J, Karlson E, Jarvik G, Ritchie M. Risk factors affecting polygenic score performance across diverse cohorts. ELife 2025, 12 DOI: 10.7554/elife.88149.3.Peer-Reviewed Original ResearchBody mass indexPolygenic scoresAssociated with body mass indexPolygenic score performancePhysical activityStandard deviation changeBMI effectsBMI individualsAlcohol consumptionDiverse cohortMass indexInteraction effectsRisk factorsBlood lipidsDeviation changeQuintileScore performanceCohortCovariatesBinary covariateAncestryContinuous covariatesModel R 2DifferencesScores
2021
Comparative Effectiveness of Clinical and Community-Based Approaches to Healthy Weight
Fiechtner L, Perkins M, Biggs V, Langhans N, Sharifi M, Price S, Luo M, Locascio JJ, Hohman KH, Hodge H, Gortmaker S, Torres S, Taveras EM. Comparative Effectiveness of Clinical and Community-Based Approaches to Healthy Weight. 2021, 148: e2021050405. PMID: 34470816, PMCID: PMC8573851, DOI: 10.1542/peds.2021-050405.Peer-Reviewed Original ResearchConceptsHealthy weightHealth centersPediatric weight management interventionsConfidence intervalsWeight management interventionsIntervention participantsEffective treatmentLow-income childrenBMIBMI effectsComparative effectivenessMean differencePercentile changeComparison groupComparison sitesNoninferiority testLinear mixed modelsNoninferiorityChild interventionChildrenInterventionMixed modelsManagement interventionsPrevious dataImportant differences
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