Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health
Lisgara A, Thompson D, Nebert D, Vasiliou V. Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health. Expert Opinion On Drug Metabolism & Toxicology 2025, 21: 915-919. PMID: 40591371, DOI: 10.1080/17425255.2025.2524872.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenaseAldehyde-oxidizing enzymesNon-P450ALDH superfamilyNitric oxide-related speciesEnzymatic diversityGenetic screeningALDH polymorphismsCytochrome P450 enzymesRedox balancePrecise risk assessmentNeurodegenerative diseasesEnvironmental stressorsClinical implicationsDetoxication functionEnzymeP450 enzymesLifetime environmental exposuresTherapeutic targetPolymorphismCellular damageDehydrogenaseEnvironmental exposuresClinical relevanceHuman health
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