Expressional and Mutational Analysis of Pro-apoptotic Bcl-2 Member PUMA in Hepatocellular Carcinomas
Ahn C, Jeong E, Kim S, Lee J, Lee S, Kim S, Kim M, Yoo N, Lee S. Expressional and Mutational Analysis of Pro-apoptotic Bcl-2 Member PUMA in Hepatocellular Carcinomas. Digestive Diseases And Sciences 2007, 53: 1395. PMID: 17934815, DOI: 10.1007/s10620-007-9987-x.Peer-Reviewed Original ResearchConceptsBcl-2 homology 3Single-strand conformation polymorphismPUMA protein expressionHuman hepatocellular carcinomaMutation analysisPUMA expressionApoptosis functionPUMA geneNon-tumorous hepatocytesBcl-2Pro-apoptotic membersBcl-2 familySomatic mutationsFunction of PUMADeregulation of apoptosisExpression of PUMACancer cellsDomain mutationsTarget of inactivationCharacteristics of human hepatocellular carcinomaHuman hepatocellular carcinoma cellsCancer developmentMechanisms of cancer developmentHepatocellular carcinomaP53-dependentImmunohistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas
Yoo N, Lee J, Jeong E, Lee S. Immunohistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas. Digestive And Liver Disease 2007, 39: 222-227. PMID: 17267315, DOI: 10.1016/j.dld.2006.11.006.Peer-Reviewed Original ResearchConceptsPro-apoptotic membersPUMA protein expressionMutation analysisPUMA proteinPro-apoptotic member of Bcl-2 familyMembers of Bcl-2 familyGastric tumourigenesisMalignant gastric epithelial cellsSingle-strand conformation polymorphismBcl-2 familyGastric carcinomaMucosal epithelial cellsExpression of PUMAAlteration of apoptosisEpithelial cellsTarget of inactivationNormal mucosal epithelial cellsMechanisms of cancer developmentImmunohistochemical analysisGastric epithelial cellsP53-dependentProtein expressionPUMA expressionPUMA geneConformation polymorphism
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