2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased riskTreating new-onset cognitive complaints after risk-reducing salpingo-oophorectomy: A randomized controlled crossover trial of lisdexamfetamine
Metcalf C, Page C, Stocker B, Johnson R, Duffy K, Sammel M, Loughead J, Epperson C. Treating new-onset cognitive complaints after risk-reducing salpingo-oophorectomy: A randomized controlled crossover trial of lisdexamfetamine. Gynecologic Oncology 2024, 190: 62-69. PMID: 39146756, PMCID: PMC11702344, DOI: 10.1016/j.ygyno.2024.07.689.Peer-Reviewed Original ResearchRisk-Reducing Salpingo-OophorectomySelf-report measures of executive functionBrown Attention Deficit Disorder ScaleMeasures of executive functionMeasures of cognitive functionWorking memory performanceExecutive function difficultiesMeasures of attentionSelf-report measuresTrial completion ratesGenetically at-riskRandomized controlled crossover trialAttention/working memoryExecutive functionWorking memoryDisorder ScaleMemory performanceSustained attentionCognitive complaintsCognitive tasksLisdexamfetamineCognitive functionActive medicationTotal scoreFunctional difficulties
2022
Network hub centrality and working memory performance in schizophrenia
Eryilmaz H, Pax M, O’Neill A, Vangel M, Diez I, Holt D, Camprodon J, Sepulcre J, Roffman J. Network hub centrality and working memory performance in schizophrenia. Schizophrenia 2022, 8: 76. PMID: 36151201, PMCID: PMC9508261, DOI: 10.1038/s41537-022-00288-y.Peer-Reviewed Original ResearchWorking memory performanceVentral attention networkMemory performanceRight superior temporal cortexAssociated with poorer performanceAssociated with cognitive performanceWorking Memory DeficitsAssociated with better performanceWorking memory accuracySuperior temporal cortexBetween-network connectivityBrain network hubsGender-matched healthy controlsGraph theory metricsMemory accuracyMemory deficitsCognitive deficitsCognitive symptomsSustained attentionTemporal cortexCognitive performanceExternal cognitionQuantifying centralityCortical hubsSchizophrenia
2017
Competitive interactions affect working memory performance for both simultaneous and sequential stimulus presentation
Ahmad J, Swan G, Bowman H, Wyble B, Nobre A, Shapiro K, McNab F. Competitive interactions affect working memory performance for both simultaneous and sequential stimulus presentation. Scientific Reports 2017, 7: 4785. PMID: 28684800, PMCID: PMC5500476, DOI: 10.1038/s41598-017-05011-x.Peer-Reviewed Original ResearchConceptsWM precisionSequential presentationMeasures of working memoryWorking memory performanceSequential stimulus presentationProximity of stimuliMemory performanceBOLD responseStimulus presentationSimultaneous presentationVisual stimuliNeural firingStimuliWMItemsParticipantsBOLDMemoryTaskPresentationSequential competitionTemporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations
van Ede F, Niklaus M, Nobre A. Temporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations. Journal Of Neuroscience 2017, 37: 437-445. DOI: 10.1523/jneurosci.2272-16.2017.Peer-Reviewed Original ResearchVisual working memoryWorking memoryTemporal expectationsAttentional prioritizationNeural substratesBrain areasStudies of working memoryFlexible goal-directed behaviorMemory retrieval timeInvestigate working memoryWorking memory performanceGoal-directed behaviorEcologically valid contextInvestigated visual working memorySensory brain areasVisual brain areasMemory performanceLaboratory tasksNeuronal underpinningsMental representationsNeural mechanismsDelay intervalNeural implementationValid contextsPrecision judgments
2016
Temporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations
van Ede F, Niklaus M, Nobre A. Temporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations. Journal Of Neuroscience 2016, 37: 437-445. PMID: 28077721, PMCID: PMC5242399, DOI: 10.1523/jneurosci.2272-16.2016.Peer-Reviewed Original ResearchConceptsVisual working memoryWorking memoryTemporal expectationsAttentional prioritizationNeural substratesBrain areasStudies of working memoryFlexible goal-directed behaviorMemory retrieval timeInvestigate working memoryWorking memory performanceGoal-directed behaviorEcologically valid contextInvestigated visual working memorySensory brain areasVisual brain areasMemory performanceLaboratory tasksNeuronal underpinningsMental representationsNeural mechanismsDelay intervalNeural implementationValid contextsPrecision judgmentsRetrospective Attention Interacts with Stimulus Strength to Shape Working Memory Performance
Wildegger T, Humphreys G, Nobre A. Retrospective Attention Interacts with Stimulus Strength to Shape Working Memory Performance. PLOS ONE 2016, 11: e0164174. PMID: 27706240, PMCID: PMC5051714, DOI: 10.1371/journal.pone.0164174.Peer-Reviewed Original ResearchConceptsWorking memoryWM performanceExperiment 2Working memory performanceRetrospective attentionWM taskWM maintenanceWM representationsStimulus contrastOrienting attentionHigh-contrast stimuliMemory performanceExperiment 3Perceptual representationsExperiment 1RetrocueLow-contrast stimuliSpatial attentionInfluence performanceStimuliSub-threshold stimuliMixture-model approachRetrospective orientationStimulus strengthEncoding
2011
Processing Speed and Working Memory Performance in Those with Both ADHD and a Reading Disorder Compared with Those with ADHD Alone
Katz LJ, Brown FC, Roth RM, Beers SR. Processing Speed and Working Memory Performance in Those with Both ADHD and a Reading Disorder Compared with Those with ADHD Alone. Archives Of Clinical Neuropsychology 2011, 26: 425-433. PMID: 21613301, DOI: 10.1093/arclin/acr026.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderReading disorderMore difficultyWorking memory performanceExecutive functioning measuresMemory measuresCognitive weaknessesMemory performanceHyperactivity disorderFunctioning measuresProcessing speedEF scoresOlder adolescentsCommon underlying featureCurrent studyDisordersUnderlying featureMemoryDifficultiesMeasuresAdolescentsChildrenAdultsPrevious studiesIndividuals
2007
Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys
James AS, Groman SM, Seu E, Jorgensen M, Fairbanks LA, Jentsch JD. Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys. Journal Of Neuroscience 2007, 27: 14358-14364. PMID: 18160643, PMCID: PMC6673444, DOI: 10.1523/jneurosci.4508-07.2007.Peer-Reviewed Original ResearchConceptsDimensions of impulsivityMemory performanceNonsocial stimuliResponse taskImpulsive behaviorDRD4 genotypeAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderSpatial Working Memory PerformanceHigh impulsive animalsWorking memory performanceDelayed response taskDimensions of temperamentLow impulsive subjectsDRD4 allelesNeurocognitive endophenotypesDopamine D4 receptor geneHyperactivity disorderD4 receptor geneDimensional phenotypesCorrect responsesDelay versionImpulsivityCeiling levelImpulsive approach
2000
Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises
Wexler BE, Anderson M, Fulbright RK, Gore JC. Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises. American Journal Of Psychiatry 2000, 157: 1694-1697. PMID: 11007730, DOI: 10.1176/appi.ajp.157.10.1694.Peer-Reviewed Original ResearchConceptsLeft inferior frontal cortexTask-related activationVerbal memory taskInferior frontal cortexMemory performanceMemory taskCognitive exercisesMemory exercisesNonverbal memory performanceWorking memory performanceVerbal memory deficitsVerbal memory dysfunctionFrontal lobe activationRegional brain activationFrontal cortexSame brain regionsBrain activationTraining periodMemory deficitsMemory dysfunctionBrain regionsPreliminary evidenceBehavioral aspectsTaskSchizophrenia
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