2021
Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level
Wang J, Maschietto F, Guberman-Pfeffer MJ, Reiss K, Allen B, Xiong Y, Lolis E, Batista VS. Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level. Computational And Structural Biotechnology Journal 2021, 19: 5019-5028. PMID: 34540146, PMCID: PMC8442599, DOI: 10.1016/j.csbj.2021.08.053.Peer-Reviewed Original ResearchMembrane fusion mechanismMembrane fusionSpike trimerNeutral amino acid transporterHost cellular membranesAmino acid transportersCentral stalkCentral poreHost membraneFusion mechanismCellular membranesAcid transportersMolecular levelViral membraneCellular levelEnzymatic activityChoreographic eventFusion peptideAntiviral inhibitorsDrug designAttractive targetInitial bindingMembraneConformational constraintsSpike glycoprotein
2018
A combinatorial approach for robust transgene delivery and targeted expression in mammary gland for generating biotherapeutics in milk, bypassing germline gene integration
Ganguli N, Ganguli N, Chandra S, Choubey M, Sarkar D, Majumdar S. A combinatorial approach for robust transgene delivery and targeted expression in mammary gland for generating biotherapeutics in milk, bypassing germline gene integration. Applied Microbiology And Biotechnology 2018, 102: 6221-6234. PMID: 29855689, DOI: 10.1007/s00253-018-9094-2.Peer-Reviewed Original ResearchConceptsΒ-casein promoterGene integrationHemagglutinin-neuraminidaseEpithelial cell-specific expressionSpecific gene expressionCell-specific expressionMammary epithelial cellsEpithelial cellsNative genomeAnimal bioreactorsMammary glandMembrane fusionGene expressionSpecific expressionTransgene constructLuminal epithelial cellsMilk glandTargeted expressionViral membraneTransgeneFarmed animalsProtein expressionTherapeutic proteinsPromoterFusion factor
2001
Vesicular Stomatitis Virus Glycoprotein Containing the Entire Green Fluorescent Protein on Its Cytoplasmic Domain Is Incorporated Efficiently into Virus Particles
Dalton K, Rose J. Vesicular Stomatitis Virus Glycoprotein Containing the Entire Green Fluorescent Protein on Its Cytoplasmic Domain Is Incorporated Efficiently into Virus Particles. Virology 2001, 279: 414-421. PMID: 11162797, DOI: 10.1006/viro.2000.0736.Peer-Reviewed Original ResearchConceptsLarge cytoplasmic domainCytoplasmic domainVSV G proteinVesicular stomatitis virusGreen fluorescent proteinG proteinsGFP proteinWild-type G proteinFluorescent proteinShort cytoplasmic domainVesicular stomatitis virus glycoproteinStrong selectionVirus particlesExtra genesHeterotrimeric proteinGFP geneProtein sequencesWild-type virusFluorescent virus particlesStop codonVirus assemblyInfectious cloneGenesViral membraneAmino acids
1980
Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus
Rose J, Welch W, Sefton B, Esch F, Ling N. Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1980, 77: 3884-3888. PMID: 6253998, PMCID: PMC349731, DOI: 10.1073/pnas.77.7.3884.Peer-Reviewed Original ResearchConceptsAmino acid sequencePartial amino acid sequenceVesicular stomatitis virus glycoproteinAcid sequenceAmino acidsProtein geneCOOH terminusHydrophobic domainViral membraneVSV G proteinLipid bilayersTerminal portionTerminal amino acid sequenceM protein geneG protein geneG protein sequencesTerminal amino acidsVirus glycoproteinErythrocyte membrane proteinsMembrane proteinsDNA insertsLeader sequenceComplete sequenceProtein sequencesRNA genome
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply