2025
Stylet cuticular gene-directed mutagenesis impairs the pea aphid vector capacity to transmit a plant virus
Fu Y, Deshoux M, Cayrol B, Le Blaye S, Achard E, Hudaverdian S, Cloteau R, Pichon E, Strozyk E, Prunier-Leterme N, Jousselin E, Sauvion N, Thébaud G, Le Trionnaire G, Colella S, Uzest M. Stylet cuticular gene-directed mutagenesis impairs the pea aphid vector capacity to transmit a plant virus. PLOS Pathogens 2025, 21: e1013192. PMID: 40408450, PMCID: PMC12140417, DOI: 10.1371/journal.ppat.1013192.Peer-Reviewed Original ResearchConceptsMutant linesCaMV transmissionPlant virusesAphid styletsRNAi-mediated silencingCauliflower mosaic virusPutative virus receptorMosaic virusInfected plantsCaMVGene-directed mutagenesisVirus receptorsAgricultural pestsVector capacityCuticular proteinsStable mutantsPlantsAcrostylePeaProtein P2AphidsVirus vectorsVirus transmissionStructural roleExposed domain
2024
Multiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera
Ferdous Z, Dieme C, Sproch H, Kramer L, Ciota A, Brackney D, Armstrong P. Multiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera. Parasites & Vectors 2024, 17: 432. PMID: 39427222, PMCID: PMC11490111, DOI: 10.1186/s13071-024-06531-y.Peer-Reviewed Original ResearchConceptsAedes aegyptiMidgut infection ratesMultiple bloodmealsVector competence of Aedes aegyptiVirus vectorsLaboratory vector competence studiesVector competence studiesMosquito generaFeeding regimenBiting midgesCulex quinquefasciatusPost-infectionOropouche virusWest Nile virusBloodmealVirus disseminationVector competenceEscape barrierFeeding behaviorDissemination of arbovirusesAedes albopictus mosquitoesAedes triseriatusAedesFemale mosquitoesNile virus
2021
Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC
Brown SC, Cormier J, Tuan J, Lier AJ, McGuone D, Armstrong PM, Kaddouh F, Parikh S, Landry ML, Gobeske KT. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2042-2051. PMID: 34289334, PMCID: PMC8314835, DOI: 10.3201/eid2708.203730.Peer-Reviewed Original Research
2020
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Vormstein-Schneider D, Lin J, Pelkey K, Chittajallu R, Guo B, Arias-Garcia M, Allaway K, Sakopoulos S, Schneider G, Stevenson O, Vergara J, Sharma J, Zhang Q, Franken T, Smith J, Ibrahim L, Mastro K, Sabri E, Huang S, Favuzzi E, Burbridge T, Xu Q, Guo L, Vogel I, Sanchez V, Saldi G, Gorissen B, Yuan X, Zaghloul K, Devinsky O, Sabatini B, Batista-Brito R, Reynolds J, Feng G, Fu Z, McBain C, Fishell G, Dimidschstein J. Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans. Nature Neuroscience 2020, 23: 1629-1636. PMID: 32807948, PMCID: PMC8015416, DOI: 10.1038/s41593-020-0692-9.Peer-Reviewed Original ResearchConceptsRecombinant adeno-associated virus vectorAdeno-associated virus vectorVasoactive intestinal peptide-expressing interneuronsClasses of neuronsGene regulatory elementsGene SCN1AViral toolsNeuronal subtypesCerebral cortexViral manipulationTherapeutic interventionsVertebrate speciesNon-human primatesVirus vectorsGene expressionInterneuronsBrain regionsCircuit manipulationsExquisite specificityParvalbuminRegulatory landscapeNeuronsSCN1ASubtypesMice
2007
Identification of a TFIID Binding Sequence That Increases Expression from the Ankyrin-1 Promoter: Application to Globin Gene Therapy
Laflamme K, Elnitski L, Wong C, Mary Y, Gallagher P, Bodine D. Identification of a TFIID Binding Sequence That Increases Expression from the Ankyrin-1 Promoter: Application to Globin Gene Therapy. Blood 2007, 110: 3741. DOI: 10.1182/blood.v110.11.3741.3741.Peer-Reviewed Original ResearchGene therapyEffective gene therapyGlobin gene therapyDifferent tissue-specific promotersTissue-specific promotersVector copiesViral vectorsDouble-copy vectorVirus vectorsHematopoietic stem cellsSpecific promotersPromoter libraryLibrary of promotersRecombinant virusesStem cellsInefficient productionRecent demonstrationReporter geneTG dinucleotideInsertional activationHigh titersΓ-globin expressionTherapeutic levelsVectorLocus control region
1999
cis Requirements for the Efficient Production of Recombinant DNA Vectors Based on Autonomous Parvoviruses
Kestler J, Neeb B, Struyf S, Van Damme J, Cotmore S, D'Abramo A, Tattersall P, Rommelaere J, Dinsart C, Cornelis J. cis Requirements for the Efficient Production of Recombinant DNA Vectors Based on Autonomous Parvoviruses. Human Gene Therapy 1999, 10: 1619-1632. PMID: 10428207, DOI: 10.1089/10430349950017626.Peer-Reviewed Original ResearchConceptsViral vectorsViral vector productionRecombinant viral vectorsRecombinant DNA vectorsVector productionRecombinant parvovirusesDNA vectorsRecombinant particlesVirus vectorsOverall sizeRecombinant vectorSmall transgenesEfficient productionHelper plasmidForeign DNAEfficient packagingPlasmid DNAParvovirus MVMpRecombinant clonesAutonomous parvovirusesViral terminiInfectious unitsVP sequencesDNA lengthVector
1992
Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR
Egan M, Flotte T, Afione S, Solow R, Zeitlin P, Carter B, Guggino W. Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR. Nature 1992, 358: 581-584. PMID: 1380129, DOI: 10.1038/358581a0.Peer-Reviewed Original ResearchConceptsCyclic AMP-dependent proteinCF geneCF bronchial epithelial cellsLethal genetic diseaseProtein kinaseDefective acidificationBronchial epithelial cellsGenetic diseasesProteinDefective regulationLarge conductanceEpithelial cellsGenesCFTRConductance pathwayCystic fibrosisLinear current-voltage relationshipVirus vectorsRegulationKinaseConductancePathwayExpressionAcidificationCells
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