2025
Genetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo
Boswell C, Hoppe C, Sherrard A, Miao L, Kojima M, Martino P, Zhao N, Stasevich T, Nicoli S, Giraldez A. Genetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo. Nature Communications 2025, 16: 5503. PMID: 40595661, PMCID: PMC12216260, DOI: 10.1038/s41467-025-61003-w.Peer-Reviewed Original ResearchConceptsFunction in vivoAffinity reagentsPlanar cell polarity protein Vangl2Gene targetingEndogenous protein localizationProtein function in vivoProtein targets in vivoModel organism communitiesKnock-in alleleConventional gene targetingProtein functionSingle chain variable fragmentTranscription factor NanogProtein localizationTargets in vivoZebrafish developmentVariable fragmentAllelesNative behaviorFluorescence visualizationOrganic communityVangl2AffinityGenesZebrafish
2016
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development
Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M. Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development 2016, 143: 4441-4451. PMID: 27789626, PMCID: PMC5201046, DOI: 10.1242/dev.140129.Peer-Reviewed Original ResearchConceptsLymphatic endothelial cellsPlanar cell polarity protein Vangl2Lymphatic vessel remodelingMouse embryonic developmentHuman lymphatic endothelial cellsVangl2 overexpressionVangl2 expressionEmbryonic developmentValve morphogenesisEndothelial cellsVasculature developmentSyndecan-4Lymphatic vasculatureFluid shear stressSDC4Double knockout miceMice resultsHigh expressionVessel remodelingLymphatic vesselsExpressionVangl2RemodelingCellsMorphogenesis
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