2025
SARS-CoV-2 Receptor Binding Domain (RBD) Protein–Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques
Scaria P, Rowe C, Kosik I, Hu Z, Renn J, Alani N, Kemanli P, Orr-Gonzalez S, Lambert L, Adeyemi K, Doritchamou J, Barnafo E, Rausch K, Muslinkina L, Morrison R, Todd J, Esposito D, Lees A, Yewdell J, Duffy P. SARS-CoV-2 Receptor Binding Domain (RBD) Protein–Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques. Vaccines 2025, 13: 648. PMID: 40573979, PMCID: PMC12197534, DOI: 10.3390/vaccines13060648.Peer-Reviewed Original ResearchVirus neutralizing activityMRNA vaccinesAntibody responseReceptor-binding domainSARS-CoV-2Rhesus macaquesNeutralizing activityIgG subclass profileEnhanced antibody responseReceptor binding inhibitionDevelopment of vaccinesPolyclonal immune seraVaccine platformSubclass profileClinical trialsSARS-CoV-2 spike proteinTarget antigenAntibody avidityVariants of SARS-CoV-2Efficacious vaccinesMultiple time pointsImmune serumEarly vaccinationSARS-CoV-2 receptor-binding domainVaccine
2023
Beluga whale and bottlenose dolphin ACE2 proteins allow cell entry mediated by spike protein from three variants of SARS-CoV-2
Stone H, Unal E, Romano T, Turner P. Beluga whale and bottlenose dolphin ACE2 proteins allow cell entry mediated by spike protein from three variants of SARS-CoV-2. Biology Letters 2023, 19: 20230321. PMID: 38053365, PMCID: PMC10698476, DOI: 10.1098/rsbl.2023.0321.Peer-Reviewed Original ResearchConceptsAngiotensin-converting enzyme 2Beluga whalesCell entrySpike proteinSpillover of SARS-CoV-2SARS-CoV-2 spike proteinWuhan-Hu-1Formation of social groupsSARS-CoV-2Susceptibility to virus infectionHost individualsAnimal hostsVariants of SARS-CoV-2Pandemic isolatesBottlenose dolphinsACE2 proteinCellular receptorsContact with humansBelugaPotential threatDolphinsProteinAnimal reservoirsEnzyme 2Mammal reservoirs
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