A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study
Ross R, Galsky M, Scher H, Magidson J, Wassmann K, Lee G, Katz L, Subudhi S, Anand A, Fleisher M, Kantoff P, Oh W. A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study. The Lancet Oncology 2012, 13: 1105-1113. PMID: 23059047, DOI: 10.1016/s1470-2045(12)70263-2.Peer-Reviewed Original ResearchConceptsCastration-resistant prostate cancerProstate cancerSix-gene modelMedian survivalMemorial Sloan-Kettering Cancer CenterSix-geneDana-Farber Cancer InstitutePredictive of survivalSignificantly higher areaLow-risk groupHigh-risk groupBiomarkers predictive of survivalProstate cancer-related genesCancer-related genesPeripheral bloodClinicopathological modelPrognostic informationPrognostic utilityTreatment regimensBiomarkers PredictiveProspective studyDana-FarberIndependent cohortPrognostic biomarkerRisk groupsA validated whole-blood RNA transcript-based prognostic model that predicts survival in men with castration-resistant prostate cancer.
Oh W, Kantoff P, Scher H, Magidson J, Wassmann K, Lee G, Katz L, Subudhi S, Anand A, Fleisher M, Galsky M, Ross R. A validated whole-blood RNA transcript-based prognostic model that predicts survival in men with castration-resistant prostate cancer. Journal Of Clinical Oncology 2012, 30: 4516-4516. DOI: 10.1200/jco.2012.30.15_suppl.4516.Peer-Reviewed Original ResearchCastration resistant prostate cancerProstate cancerCastration resistant prostate cancer diagnosisCastration resistant prostate cancer patientsCastration-resistant prostate cancerImmune-based therapeutic strategiesRisk menResistant prostate cancerTime of blood drawPredictive of survivalLow-risk menHigh-risk menTranscriptional profiling of whole bloodBiomarkers predictive of survivalProstate cancer-related genesCohort of menCancer-related genesPredictive biomarkersPeripheral bloodPrognostic informationTreatment regimensBiomarkers PredictivePolymerase chain reactionPatient stratificationClinical trials
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