2008
Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors
Morton J, Klimstra D, Mongeau M, Lewis B. Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors. American Journal Of Pathology 2008, 172: 1081-1087. PMID: 18310506, PMCID: PMC2276406, DOI: 10.2353/ajpath.2008.070778.Peer-Reviewed Original ResearchConceptsPancreas-specific deletionTrp53 deletionTumor typesTumor progressionAnalysis of metastatic lesionsPresence of distant metastasesPancreatic cancer mouse modelDiagnosis of pancreatic cancerMetastatic pancreatic tumorsAssociated with tumor progressionP53 loss of functionAccelerated tumor developmentPancreatic tumor progressionCancer mouse modelPancreatic ductal adenocarcinomaHuman pancreatic carcinomaTumor suppressor locusPancreatic cancer metastasisPancreatic cancer progressionP53 tumor suppressor proteinMetastatic lesionsDistant metastasisPancreatic tumorsPancreatic carcinomaHaploinsufficient manner
2007
Loss of p53 and Ink4a/Arf Cooperate in a Cell Autonomous Fashion to Induce Metastasis of Hepatocellular Carcinoma Cells
Chen Y, Klimstra D, Mongeau M, Tatem J, Boyartchuk V, Lewis B. Loss of p53 and Ink4a/Arf Cooperate in a Cell Autonomous Fashion to Induce Metastasis of Hepatocellular Carcinoma Cells. Cancer Research 2007, 67: 7589-7596. PMID: 17699762, PMCID: PMC2396788, DOI: 10.1158/0008-5472.can-07-0381.Peer-Reviewed Original ResearchConceptsTumor suppressor locusHepatocellular carcinomaSuppressor locusInvasive activity in vitroINK4a/ARF tumor suppressor locusMetastatic HCC modelP53 loss of functionLoss of p53Cell-autonomous fashionHepatocellular carcinoma patientsCancer-related deathsMetastasis of hepatocellular carcinoma cellsLiver progenitor cellsLiver-specific deletionCell-autonomous effectsHepatocellular carcinoma metastasisLoss of functionTumor cell linesHepatocellular carcinoma cellsLymph nodesHCC modelModel systemPoor prognosisPortal veinTumor suppressor
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