Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors
Morton J, Klimstra D, Mongeau M, Lewis B. Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors. American Journal Of Pathology 2008, 172: 1081-1087. PMID: 18310506, PMCID: PMC2276406, DOI: 10.2353/ajpath.2008.070778.Peer-Reviewed Original ResearchConceptsPancreas-specific deletionTrp53 deletionTumor typesTumor progressionAnalysis of metastatic lesionsPresence of distant metastasesPancreatic cancer mouse modelDiagnosis of pancreatic cancerMetastatic pancreatic tumorsAssociated with tumor progressionP53 loss of functionAccelerated tumor developmentPancreatic tumor progressionCancer mouse modelPancreatic ductal adenocarcinomaHuman pancreatic carcinomaTumor suppressor locusPancreatic cancer metastasisPancreatic cancer progressionP53 tumor suppressor proteinMetastatic lesionsDistant metastasisPancreatic tumorsPancreatic carcinomaHaploinsufficient manner
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