2013
Endothelial Cell–Dependent Regulation of Arteriogenesis
Moraes F, Paye J, Mac Gabhann F, Zhuang ZW, Zhang J, Lanahan AA, Simons M. Endothelial Cell–Dependent Regulation of Arteriogenesis. Circulation Research 2013, 113: 1076-1086. PMID: 23897694, PMCID: PMC3865810, DOI: 10.1161/circresaha.113.301340.Peer-Reviewed Original ResearchConceptsAdult arteriogenesisCell-autonomous fashionGrowth factor signalingMouse linesCell-autonomous effectsKnockin mouse lineMorphogenetic defectsArterial morphogenesisCell type-specific deletionFactor signalingCell typesCre-driver mouse linesSynectinAttractive therapeutic strategyOcclusive atherosclerotic diseaseMuscle cellsEndothelial cellsRegulationArterial conduitsAtherosclerotic diseaseTherapeutic strategiesAdult miceClinical importanceArteriogenesisCells
2012
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development
Prendergast A, Linbo TH, Swarts T, Ungos JM, McGraw HF, Krispin S, Weinstein BM, Raible DW. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development 2012, 139: 1141-1152. PMID: 22296847, PMCID: PMC3283124, DOI: 10.1242/dev.072439.Peer-Reviewed Original ResearchConceptsRECK functionsNeural crestForward genetic screenCell fate specificationMultipotent cell lineagesCell-autonomous fashionCysteine-rich proteinNeural crest cellsSensory neuron formationReversion-inducing cysteine-rich proteinGenetic screenInhibitors of metalloproteinasesFate specificationSensory neuron precursorsCell motilityCrest cellsCell lineagesProper migrationDRG formationDRG developmentNeuron formationMyriad tissuesKazal motifsNeuron precursorsGenes
2007
Loss of p53 and Ink4a/Arf Cooperate in a Cell Autonomous Fashion to Induce Metastasis of Hepatocellular Carcinoma Cells
Chen Y, Klimstra D, Mongeau M, Tatem J, Boyartchuk V, Lewis B. Loss of p53 and Ink4a/Arf Cooperate in a Cell Autonomous Fashion to Induce Metastasis of Hepatocellular Carcinoma Cells. Cancer Research 2007, 67: 7589-7596. PMID: 17699762, PMCID: PMC2396788, DOI: 10.1158/0008-5472.can-07-0381.Peer-Reviewed Original ResearchConceptsTumor suppressor locusHepatocellular carcinomaSuppressor locusInvasive activity in vitroINK4a/ARF tumor suppressor locusMetastatic HCC modelP53 loss of functionLoss of p53Cell-autonomous fashionHepatocellular carcinoma patientsCancer-related deathsMetastasis of hepatocellular carcinoma cellsLiver progenitor cellsLiver-specific deletionCell-autonomous effectsHepatocellular carcinoma metastasisLoss of functionTumor cell linesHepatocellular carcinoma cellsLymph nodesHCC modelModel systemPoor prognosisPortal veinTumor suppressor
1997
liguleless1 encodes a nuclear-localized protein required for induction of ligules and auricles during maize leaf organogenesis.
Moreno M, Harper L, Krueger R, Dellaporta S, Freeling M. liguleless1 encodes a nuclear-localized protein required for induction of ligules and auricles during maize leaf organogenesis. Genes & Development 1997, 11: 616-628. PMID: 9119226, DOI: 10.1101/gad.11.5.616.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceCell NucleusCloning, MolecularDNA Transposable ElementsDNA-Binding ProteinsGene Expression Regulation, PlantGerm-Line MutationMolecular Sequence DataMutationPhenotypePlant LeavesPlant ProteinsPolymerase Chain ReactionRecombinant Fusion ProteinsRNA, MessengerRNA-Binding ProteinsSequence Homology, Amino AcidZea maysConceptsBlade-sheath boundaryMaize leaf primordiaCell-autonomous fashionGene product functionsActivator (Ac) transposable elementAmino acid sequenceCellular localization studiesLeaf organogenesisLigular regionPlastochron 6Transposable elementsLeaf primordiaRT-PCR analysisMaize leavesCDNA cloningHeterologous systemsAcid sequenceRevertant sectorsGene expressionSignificant similarityMolecular tagsLocalization studiesLiguleAmino acidsProtein 1
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