2008
Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors
Morton J, Klimstra D, Mongeau M, Lewis B. Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors. American Journal Of Pathology 2008, 172: 1081-1087. PMID: 18310506, PMCID: PMC2276406, DOI: 10.2353/ajpath.2008.070778.Peer-Reviewed Original ResearchConceptsPancreas-specific deletionTrp53 deletionTumor typesTumor progressionAnalysis of metastatic lesionsPresence of distant metastasesPancreatic cancer mouse modelDiagnosis of pancreatic cancerMetastatic pancreatic tumorsAssociated with tumor progressionP53 loss of functionAccelerated tumor developmentPancreatic tumor progressionCancer mouse modelPancreatic ductal adenocarcinomaHuman pancreatic carcinomaTumor suppressor locusPancreatic cancer metastasisPancreatic cancer progressionP53 tumor suppressor proteinMetastatic lesionsDistant metastasisPancreatic tumorsPancreatic carcinomaHaploinsufficient manner
2000
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
Shao C, Deng L, Henegariu O, Liang L, Stambrook P, Tischfield J. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7405-7410. PMID: 10861008, PMCID: PMC16558, DOI: 10.1073/pnas.97.13.7405.Peer-Reviewed Original ResearchConceptsGenetic instabilityChromosome instabilityP53-null miceP53 tumor suppressor proteinMultiple cellular processesCell cycle checkpointsTumor suppressor proteinSomatic cell variantsNormal cellsNull miceCellular processesCycle checkpointsGenetic variationMitotic recombinationSuppressor proteinEpigenetic alterationsInterstitial deletionLOH eventsCell deathLoss of heterozygosityP53 functionFibroblast coloniesPoint mutationsFunctional p53Tumor initiation
1999
p53, mdm-2, and p21 waf-1 in the Porokeratoses
Nelson C, Cowper S, Morgan M. p53, mdm-2, and p21 waf-1 in the Porokeratoses. American Journal Of Dermatopathology 1999, 21: 420. PMID: 10535569, DOI: 10.1097/00000372-199910000-00003.Peer-Reviewed Original ResearchConceptsTypes of porokeratosisCyclin-dependent kinase inhibitor p21P53 stainingP53 tumor suppressor gene productCornoid lamellaP21 expressionPorokeratosesCell cycle progressionMdm-2Waf-1Inhibitor p21Potential roleTumor suppressor gene productP53 tumor suppressor proteinP21 proteinSuppressor gene productCycle progressionMDM2Tumor suppressor proteinGene productsP53Cell cycle controlPrevious findingsP21Suppressor protein
1996
Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene.
Hwang E, Naeger L, DiMaio D. Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene. Oncogene 1996, 12: 795-803. PMID: 8632901.Peer-Reviewed Original ResearchMeSH KeywordsBovine papillomavirus 1CDC2-CDC28 KinasesCell DivisionCyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesCyclinsDNA ReplicationDNA-Binding ProteinsEnzyme InhibitorsFemaleGene Expression Regulation, NeoplasticGene Expression Regulation, ViralGenes, ViralHeLa CellsHumansModels, BiologicalPhosphorylationProtein Serine-Threonine KinasesTumor Suppressor Protein p53Uterine Cervical NeoplasmsViral ProteinsConceptsTumor suppressor proteinGrowth inhibitory pathwaySuppressor proteinHeLa cellsP21/waf1Kinase activityE2 geneBPV E2 proteinP53 tumor suppressor proteinCdk2/cyclin E kinase activityCyclin-dependent kinase inhibitorGrowth regulatory pathwaysHeLa cervical carcinoma cellsP53-responsive genesCell cycle regulatory proteinsCDK kinase activityCyclin E kinase activityCycle regulatory proteinsDependent kinase inhibitorG1 cell cycle regulatory proteinsB-MybTranscription factorsRegulatory proteinsRegulatory pathwaysP105Rb
1993
Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
Hwang E, Riese D, Settleman J, Nilson L, Honig J, Flynn S, DiMaio D. Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. Journal Of Virology 1993, 67: 3720-3729. PMID: 8389903, PMCID: PMC237735, DOI: 10.1128/jvi.67.7.3720-3729.1993.Peer-Reviewed Original ResearchConceptsBPV E2 proteinGene expressionCervical carcinoma cell linesRegulatory genesHPV gene expressionCarcinoma cell linesCell linesE2 proteinHeLa cellsConsequence of abrogationP53 tumor suppressor proteinHPV18 E6Tumor suppressor proteinE2 geneDestabilization of p53HT-3 cellsGrowth inhibitionBPV E2Simian virus 40Suppressor proteinEpithelial cell lineHuman papillomavirus E6Cell cycleGenesS phase
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