2015
Reversible induction of translational isoforms of p53 in glucose deprivation
Khan D, Katoch A, Das A, Sharathchandra A, Lal R, Roy P, Das S, Chattopadhyay S, Das S. Reversible induction of translational isoforms of p53 in glucose deprivation. Cell Death & Differentiation 2015, 22: 1203-1218. PMID: 25721046, PMCID: PMC4572868, DOI: 10.1038/cdd.2014.220.Peer-Reviewed Original ResearchConceptsIRES activityP53 isoformsMaster transcription regulatorTumor suppressor protein p53Bicistronic reporter constructCritical tumor suppressorSuppressor protein p53Glucose deprivationFull-length p53P53 IRES activityP53 mRNACell cycle arrestTranscription regulatorsNutrient starvationTranslational regulationEndoplasmic reticulum stressDifferent stress conditionsNuclear proteinsInternal ribosome entry site (IRES) structureGlucose starvationTarget genesCellular pathwaysStarvation-induced increaseReporter constructsTumor suppressor
2014
Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasia
Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X. Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 10215-10220. PMID: 24982158, PMCID: PMC4104891, DOI: 10.1073/pnas.1311395111.Peer-Reviewed Original ResearchConceptsStem cell activationStem/progenitor cellsEarly progenitor cellsProgenitor cellsWnt/β-catenin targetsΒ-catenin functionStem cellsTumor suppressor protein p53Β-catenin targetsWnt/β-catenin functionsCell cycle entryAdult stem cellsHair follicle stem cellsSuppressor protein p53Chromatin factorsFollicle stem cellsProgenitor cell compartmentHomeobox proteinEpigenetic mechanismsCell activationCycle entryDownstream eventsPathway functionOrgan regenerationImportant regulator
1995
p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells.
Havre P, Yuan J, Hedrick L, Cho K, Glazer P. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Research 1995, 55: 4420-4. PMID: 7671255.Peer-Reviewed Original ResearchConceptsHigh-risk E6P53 inactivationHPV16 E6Low-risk E6Human papillomavirus proteinsG1 arrestCell linesHPV16 E6 geneHPV11 E6Carcinoma cell linesColon carcinoma cell linePapillomavirus proteinsLow dosesHPV16 E7E6 geneClonal cell linesE7 bindsNormal p53RKO cellsTumor suppressor protein p53P53 degradationSuppressor protein p53P53E6Protein p53
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