2001
Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c‐ret, directs lac Z (β‐galactosidase) expression in developing somatosensory system
Sukumaran M, Waxman S, Wood J, Pachnis V. Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c‐ret, directs lac Z (β‐galactosidase) expression in developing somatosensory system. Developmental Dynamics 2001, 222: 389-402. PMID: 11747074, DOI: 10.1002/dvdy.1192.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBase SequenceChromosome MappingCloning, MolecularConsensus SequenceDrosophila ProteinsEmbryo, MammalianGanglia, SensoryGene ExpressionGene Expression Regulation, DevelopmentalGenes, RegulatorGlial Cell Line-Derived Neurotrophic Factor ReceptorsLac OperonLectinsMiceMice, TransgenicNeurons, AfferentNociceptorsPromoter Regions, GeneticProtein Structure, TertiaryProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesSpinal CordTranscription Initiation SiteConceptsRegulatory domainLac Z expressionZ expressionCell type-specific expressionDistal regulatory domainEndogenous gene expressionCis-regulatory domainsTranscription initiation siteEntire structural geneSpecific regulatory domainsLac Z reporter geneStructural geneMouse genomeLateral mesodermRegulatory sequencesCpG islandsDNA sequencesPrimitive streakReporter geneFlanking sequencesCosmid contigGene expressionSpecific expressionTransgenic mouse lineInitiation site
1982
The 5- flanking sequences of Drosophila tRNAArg genes control their in vitro transcription in a Drosophila cell extract.
Dingermann T, Burke D, Sharp S, Schaack J, Söll D. The 5- flanking sequences of Drosophila tRNAArg genes control their in vitro transcription in a Drosophila cell extract. Journal Of Biological Chemistry 1982, 257: 14738-14744. PMID: 6924656, DOI: 10.1016/s0021-9258(18)33342-8.Peer-Reviewed Original ResearchConceptsDrosophila tRNAArg geneTRNAArg geneDrosophila Kc cell extractFlanking sequencesTranscription efficiencyCell extractsDrosophila cell extractsEfficiency of transcriptionRegion 42ATranscriptional componentsGene clusterDrosophila extractsEfficient transcriptionTranscription factorsChromosome 2HeLa extractsTranscriptionGenesHeLa cellsSpecific sequencesHomologous extractsSequenceArgDeletionExtractSomatic cell hybridization of growth hormone-producing rat pituitary cells and mouse fibroblasts results in extinction of growth hormone expression via a defect in growth hormone RNA production.
Strobl J, Dannies P, Thompson E. Somatic cell hybridization of growth hormone-producing rat pituitary cells and mouse fibroblasts results in extinction of growth hormone expression via a defect in growth hormone RNA production. Journal Of Biological Chemistry 1982, 257: 6588-6594. PMID: 6176584, DOI: 10.1016/s0021-9258(20)65183-3.Peer-Reviewed Original ResearchConceptsMouse GH geneGH geneHybrid cellsHybrid cell DNAHigh molecular weight precursorNon-pituitary cellsSomatic cell hybridizationMolecular weight precursorMultiple restriction enzymesStructural geneTranscript degradationMature mRNARestriction enzyme analysisIncomplete transcriptsFlanking sequencesParental cell lineTranscriptional blockRestriction enzyme digestionRNA productionSouthern hybridizationCell hybridizationMRNA sequencesFibroblasts resultsGrowth hormone expressionMouse fibroblast cellsTHE IN VITRO TRANSCRIPTION OF DROSOPHILA tRNA GENES
Dingermann T, Sharp S, Schaack J, DeFranco D, Johnson D, Cooley L, Söll D. THE IN VITRO TRANSCRIPTION OF DROSOPHILA tRNA GENES. 1982, 219-234. DOI: 10.1016/b978-0-12-525960-6.50021-3.Peer-Reviewed Original ResearchT-control regionDrosophila tRNA genesTRNA genesTranscription initiationGene-specific transcription factorsD-control regionMutant tRNA genesDrosophila Kc cellsSpecific transcription factorsMature tRNATranscription complexTermination signalKc cellsPrimary transcriptTranscription factorsControl regionFactor bindingGene transcriptionLeader sequenceFactor bindsPurine triphosphatesRich stretchEfficient terminationD-loopFlanking sequences
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