2020
Electronic cigarettes promotes the lung colonization of human breast cancer in NOD-SCID-Gamma mice.
Huynh D, Huang J, Le LTT, Liu D, Liu C, Pham K, Wang H. Electronic cigarettes promotes the lung colonization of human breast cancer in NOD-SCID-Gamma mice. International Journal Of Clinical And Experimental Pathology 2020, 13: 2075-2081. PMID: 32922603, PMCID: PMC7476960.Peer-Reviewed Original ResearchE-cigsNOD-SCIDGamma miceTumor cellsCig vapour extractElectronic cigarette smokingHuman breast cancer cell line MDA-MB-231Breast cancer cell line MDA-MB-231Cancer cell line MDA-MB-231Human breast cancer cellsCell line MDA-MB-231E-cig exposureHuman breast cancerMetastasis-promoting effectsTail vein injectionBreast cancer cellsTumor cell proliferationMDA-MB-231Tumor cell apoptosisCig exposureCigarette smokingLung metastasesTumor loadTumor mortalityBreast cancer
2011
Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells
Cheng B, Ling C, Dai Y, Lu Y, Glushakova L, Gee S, McGoogan K, Aslanidi G, Park M, Stacpoole P, Siemann D, Liu C, Srivastava A, Ling C. Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells. Gene Therapy 2011, 19: 375-384. PMID: 21776025, PMCID: PMC3519243, DOI: 10.1038/gt.2011.105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCarcinoma, HepatocellularCell Line, TumorDependovirusFemaleGenetic VectorsHumansLiver NeoplasmsMiceMutagenesis, Site-DirectedProteasome InhibitorsProtein Structure, TertiaryProto-Oncogene Proteins c-metTransduction, GeneticTransplantation, HeterologousTyrosineVirus IntegrationConceptsHigh-efficiency transductionAAV3 vectorsTransduction efficiencySerotype vectorsSurface-exposed tyrosinePotential gene therapyHuman hepatocyte growth factor receptorHuman liver cancer cellsGene therapyLiver cancer cellsTransgene expressionVector entryAAV3 capsidsDirect intratumoral injectionAAV3Tail vein injectionLiver tumor cellsIntratumoral injectionCancer cellsEfficiencyAdenoVectorIntracellular kinase domainVirus serotypes
2008
Preclinical Evaluation of Adjuvant Therapy with AMD3100 for Drug Resistant Philadelphia Chromosome Positive and Negative ALL
Jiang E, Yu M, Hsieh Y, DeLaTorre B, Kadavallore A, Scharman C, Park E, Yang A, Muschen M, Groffen J, Heisterkamp N, Kim Y. Preclinical Evaluation of Adjuvant Therapy with AMD3100 for Drug Resistant Philadelphia Chromosome Positive and Negative ALL. Blood 2008, 112: 2922. DOI: 10.1182/blood.v112.11.2922.2922.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaNOD/SCIDDrug-resistant leukemia cellsResistant leukemia cellsLeukemia cellsPreclinical evaluationPre-clinical xenograft modelNOD/SCID miceAcute lymphoblastic leukemia cellsCombination of AMD3100Different chemotherapeutic regimensNew treatment modalitiesLong-term survivalPrimary lymphoid organsLymphoblastic leukemia cellsTail vein injectionFurther preclinical evaluationCXCL12-CXCR4 interactionProgression of leukemiaB cell precursorsHigh death rateInteraction of CXCL12Clear beneficial effectPhiladelphia Chromosome PositiveBone marrow fibroblastsBCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia
Duy C, Yu J, Cerchietti L, Klemm L, Nahar R, Kim Y, Heisterkamp N, Martinelli G, Hofmann W, Jumaa H, Melnick A, Ye B, Muschen M. BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia. Blood 2008, 112: 295. DOI: 10.1182/blood.v112.11.295.295.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaGerminal center B cellsImatinib treatmentBCR-ABL1Bone marrowB cellsLymphoblastic leukemiaHuman BCR-ABL1NOD/SCID miceFunction of Bcl6Inhibition of BCL6Low-dose imatinibBCL6 expressionLeukemia cellsP53 signalingProtein levelsCombination of imatinibGerminal center B cell survivalTail vein injectionNovel treatment conceptsTranscriptional repressor BCL6B cell survivalLow proliferation rateRecipient miceSCID mice
2003
Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression
Chang S, Khoo C, Naylor M, Maser R, DePinho R. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes & Development 2003, 17: 88-100. PMID: 12514102, PMCID: PMC195968, DOI: 10.1101/gad.1029903.Peer-Reviewed Original ResearchConceptsInk4a/Lung metastasesSubcutaneous tumorsTumor progressionTelomerase activationSubcutaneous tumor formationAdvanced human cancersTail vein injectionTelomere dysfunctionLate passagesMalignant endpointsTelomerase-independent alternative lengtheningImmunocompromised miceFunctional differencesCytogenetic profileMetastatic activityDysfunctionMetastasisCancer cell genomeTumor formationChromosomal aberrationsHuman cancersMarked increaseInitiated cellsMouse embryonic fibroblast cultures
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply