2024
Repurposing mebendazole against triple-negative breast cancer CNS metastasis
Rodrigues A, Chernikova S, Wang Y, Trinh T, Solow-Cordero D, Alexandrova L, Casey K, Alli E, Aggarwal A, Quill T, Koegel A, Feldman B, Ford J, Hayden-Gephart M. Repurposing mebendazole against triple-negative breast cancer CNS metastasis. Journal Of Neuro-Oncology 2024, 168: 125-138. PMID: 38563850, PMCID: PMC11093727, DOI: 10.1007/s11060-024-04654-x.Peer-Reviewed Original ResearchConceptsMDA-MB-231-BRCentral nervous systemLeptomeningeal diseaseBreast cancer subtypesCNS metastasesLeptomeningeal spreadCancer subtypesCentral nervous system metastasesInternal carotid artery injectionPurposeTriple-negative breast cancerTNBC cell line MDA-MB-231Brain metastasis modelEffective oral agentBALB/c athymic nude miceLimited treatment optionsCell line MDA-MB-231In vitro migration assayAthymic nude miceCentral nervous system pathologyMigration assaySpread of cancerMDA-MB-231Oral agentsTreatment optionsEffect of mebendazole
2020
Electronic cigarettes promotes the lung colonization of human breast cancer in NOD-SCID-Gamma mice.
Huynh D, Huang J, Le LTT, Liu D, Liu C, Pham K, Wang H. Electronic cigarettes promotes the lung colonization of human breast cancer in NOD-SCID-Gamma mice. International Journal Of Clinical And Experimental Pathology 2020, 13: 2075-2081. PMID: 32922603, PMCID: PMC7476960.Peer-Reviewed Original ResearchE-cigsNOD-SCIDGamma miceTumor cellsCig vapour extractElectronic cigarette smokingHuman breast cancer cell line MDA-MB-231Breast cancer cell line MDA-MB-231Cancer cell line MDA-MB-231Human breast cancer cellsCell line MDA-MB-231E-cig exposureHuman breast cancerMetastasis-promoting effectsTail vein injectionBreast cancer cellsTumor cell proliferationMDA-MB-231Tumor cell apoptosisCig exposureCigarette smokingLung metastasesTumor loadTumor mortalityBreast cancer
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