2006
Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California
Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 578-581. PMID: 16537719, DOI: 10.1158/1055-9965.epi-05-0833.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionCaliforniaChildChild, PreschoolCohort StudiesCore Binding Factor Alpha 2 SubunitCytogeneticsFemaleGene Expression Regulation, NeoplasticGenetic MarkersGenetic Predisposition to DiseaseHispanic or LatinoHumansIn Situ Hybridization, FluorescenceIncidenceInfantMaleOncogene Proteins, FusionPloidiesPrecursor Cell Lymphoblastic Leukemia-LymphomaProbabilityProspective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSex DistributionSurvival RateWhite PeopleConceptsAcute lymphoblastic leukemia patientsNon-Hispanic whitesLymphoblastic leukemia patientsLeukemia patientsB-lineage acute lymphoblastic leukemia patientsNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyChildhood leukemia patientsEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsLymphoblastic leukemiaRisk factorsEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profilePatientsMLL rearrangementsLeukemia Study
2005
Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California.
Aldrich M, Zhang L, Wiemels J, Ma X, Loh M, Selvin S, Feusner J, Smith M, Buffler P. Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California. Blood 2005, 106: 4536. DOI: 10.1182/blood.v106.11.4536.4536.Peer-Reviewed Original ResearchNon-Hispanic whitesChildhood leukemia patientsRisk factorsLeukemia patientsMLL rearrangementsChildhood acute lymphoblastic leukemiaNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyFirst large studyEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsCytogenetic characteristicsHeterogeneity of leukemiaLymphoblastic leukemiaEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profileDistinct etiologies
2003
Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression
Chang S, Khoo C, Naylor M, Maser R, DePinho R. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes & Development 2003, 17: 88-100. PMID: 12514102, PMCID: PMC195968, DOI: 10.1101/gad.1029903.Peer-Reviewed Original ResearchConceptsInk4a/Lung metastasesSubcutaneous tumorsTumor progressionTelomerase activationSubcutaneous tumor formationAdvanced human cancersTail vein injectionTelomere dysfunctionLate passagesMalignant endpointsTelomerase-independent alternative lengtheningImmunocompromised miceFunctional differencesCytogenetic profileMetastatic activityDysfunctionMetastasisCancer cell genomeTumor formationChromosomal aberrationsHuman cancersMarked increaseInitiated cellsMouse embryonic fibroblast cultures
2001
Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse
Chang S, Khoo C, DePinho R. Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse. Seminars In Cancer Biology 2001, 11: 227-238. PMID: 11407947, DOI: 10.1006/scbi.2000.0374.Peer-Reviewed Original ResearchConceptsComplex cytogenetic profileHuman carcinomasChromosomal structural aberrationsTelomerase-deficient miceEukaryotic chromosomesNucleoprotein complexesGenomic instabilitySpecies distinctionP53 mutant miceChromosomal instabilityTumor suppressor gene mutationsShort telomeresSuppressor gene mutationsMutant miceStructural aberrationsEpithelial carcinogenesisGene mutationsCytogenetic profileChromosomesTelomeresMiceMutationsRegulationHumansAneuploidy
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