2025
Short‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study
Zhang S, Chu L, Lu Y, Wei J, Dubrow R, Chaudhry S, Spatz E, Krumholz H, Chen K. Short‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study. GeoHealth 2025, 9: e2024gh001234. PMID: 39968338, PMCID: PMC11833228, DOI: 10.1029/2024gh001234.Peer-Reviewed Original ResearchAcute myocardial infarction subtypeShort-term associationsAcute myocardial infarctionAcute myocardial infarction onsetAMI riskEffect modificationAssociated with increased AMI riskParticipant's home addressNon-Hispanic blacksNon-ST-segment elevation acute myocardial infarctionNon-Hispanic whitesCase-crossover designType 1 AMIConditional logistic regressionIncreased AMI riskMyocardial infarction onsetType 2 AMIAcute myocardial infarction patientsST-segment elevation acute myocardial infarctionLifestyle factorsSociodemographic statusHome addressUS hospitalsStratified analysisSpatiotemporal deep learning approach
2018
Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction
Lichtman JH, Leifheit EC, Safdar B, Bao H, Krumholz HM, Lorenze NP, Daneshvar M, Spertus JA, D'Onofrio G. Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction. Circulation 2018, 137: 781-790. PMID: 29459463, PMCID: PMC5822747, DOI: 10.1161/circulationaha.117.031650.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPerception of symptomsChest painCare-seeking behaviorSymptom presentationYounger patientsMyocardial infarctionST-segment elevation acute myocardial infarctionMultivariable hierarchical logistic regressionIndex AMI hospitalizationMajority of womenHierarchical logistic regressionStress/anxietyVIRGO StudyMuscle painPatient characteristicsPredominant symptomAMI symptomsPerceive symptomsProdromal symptomsPatient interviewsHeart diseasePainAMI hospitalizationUS hospitals
2016
Impact of gender on infarct size, ST-segment resolution, myocardial blush and clinical outcomes after primary stenting for acute myocardial infarction: Substudy from the EMERALD trial
Ng VG, Mori K, Costa RA, Kish M, Mehran R, Urata H, Saku K, Stone GW, Lansky AJ. Impact of gender on infarct size, ST-segment resolution, myocardial blush and clinical outcomes after primary stenting for acute myocardial infarction: Substudy from the EMERALD trial. International Journal Of Cardiology 2016, 207: 269-276. PMID: 26808991, DOI: 10.1016/j.ijcard.2016.01.013.Peer-Reviewed Original ResearchConceptsPrimary percutaneous interventionAcute myocardial infarctionST-segment resolutionInfarct sizeMyocardial infarctionST-segment elevation acute myocardial infarctionPrimary PCIPrior acute myocardial infarctionElevation acute myocardial infarctionComplete ST resolutionSmaller infarct sizeDistal protection devicesSmall vessel sizeGender-specific factorsDistal protectionEMERALD trialLAD infarctsMore hypertensionWorse comorbiditiesMidterm outcomesPrimary stentingSegment resolutionAMI patientsClinical outcomesST resolution
2011
National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention
Herrin J, Miller LE, Turkmani DF, Nsa W, Drye EE, Bernheim SM, Ling SM, Rapp MT, Han LF, Bratzler DW, Bradley EH, Nallamothu BK, Ting HH, Krumholz HM. National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 171: 1879-1886. PMID: 22123793, PMCID: PMC4312661, DOI: 10.1001/archinternmed.2011.481.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDIDO timeCoronary interventionST-segment elevation acute myocardial infarctionMixed-effects multivariable modelElevation acute myocardial infarctionPrimary percutaneous coronary interventionMedian DIDO timeAcute myocardial infarctionFibrinolytic therapyPatient characteristicsMultivariable analysisEmergency departmentMyocardial infarctionHospital characteristicsMultivariable modelPatientsRural hospitalsHospitalMedicaid ServicesAge categoriesInterventionAfrican AmericansMinutesTreatment timeImpact of Leukocyte Count on Mortality and Bleeding in Patients With Myocardial Infarction Undergoing Primary Percutaneous Coronary Interventions
Palmerini T, Mehran R, Dangas G, Nikolsky E, Witzenbichler B, Guagliumi G, Dudek D, Genereux P, Caixeta A, Rabbani L, Weisz G, Parise H, Fahy M, Xu K, Brodie B, Lansky A, Stone GW. Impact of Leukocyte Count on Mortality and Bleeding in Patients With Myocardial Infarction Undergoing Primary Percutaneous Coronary Interventions. Circulation 2011, 123: 2829-2837. PMID: 21632496, DOI: 10.1161/circulationaha.110.985564.Peer-Reviewed Original ResearchConceptsWhite blood cell countPeak creatinine phosphokinase levelCreatinine phosphokinase levelsPercutaneous coronary interventionST-segment elevation acute myocardial infarctionBaseline white blood cell countCoronary interventionAcute myocardial infarctionIndependent predictorsNoncardiac mortalityCardiac mortalityMyocardial infarctionMajor bleedingHigher white blood cell countLower white blood cell countPropensity-adjusted multivariable analysisAcute Myocardial Infarction trialPrimary percutaneous coronary interventionMyocardial Infarction trialVentricular ejection fractionSubgroup of patientsBlood cell countHarmonizing OutcomesCause mortalityEjection fraction
2010
THE IMPACT OF LEFT VENTRICULAR FUNCTION ON MORTALITY IN PATIENTS WITH ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION: ANALYSIS OF THE HARMONIZING OUTCOMES WITH REVASCULARIZATION AND STENTS IN ACUTE MYOCARDIAL INFARCTION (HORIZONS-AMI) STUDY
Lansky A, Ng V, Witzenbichler B, Guagliumi G, Peruga J, Goto K, Parise H, Mehran R, Stone G. THE IMPACT OF LEFT VENTRICULAR FUNCTION ON MORTALITY IN PATIENTS WITH ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION: ANALYSIS OF THE HARMONIZING OUTCOMES WITH REVASCULARIZATION AND STENTS IN ACUTE MYOCARDIAL INFARCTION (HORIZONS-AMI) STUDY. Journal Of The American College Of Cardiology 2010, 55: a186.e1741. DOI: 10.1016/s0735-1097(10)61742-1.Peer-Reviewed Original Research
2007
Comparison of Myocardial Reperfusion in Patients Undergoing Percutaneous Coronary Intervention in ST-Segment Elevation Acute Myocardial Infarction With Versus Without Diabetes Mellitus (from the EMERALD Trial)
Marso SP, Miller T, Rutherford BD, Gibbons RJ, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Mehran R, Krucoff MW, Lansky AJ, Stone GW. Comparison of Myocardial Reperfusion in Patients Undergoing Percutaneous Coronary Intervention in ST-Segment Elevation Acute Myocardial Infarction With Versus Without Diabetes Mellitus (from the EMERALD Trial). The American Journal Of Cardiology 2007, 100: 206-210. PMID: 17631071, DOI: 10.1016/j.amjcard.2007.02.080.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionElevation myocardial infarctionPrimary PCIMyocardial blush gradeCongestive heart failurePercutaneous coronary interventionMyocardial infarctionNondiabetic patientsDiabetes mellitusInfarct sizeMyocardial perfusionBlush gradeCoronary interventionHeart failureMyocardial reperfusionDiabetic patientsAcute ST-segment elevation myocardial infarctionST-segment elevation acute myocardial infarctionFinal myocardial blush gradeVersus Without Diabetes MellitusElevation acute myocardial infarctionSevere congestive heart failureDistal embolic protectionFinal infarct size
2001
The Connecticut Cardiovascular Consortium: a unique, state-wide research collaboration to advance clinical outcomes in patients with heart disease.
Boden WE, McKay RG, Cabin HS, Radford MJ, Krumholz HM, Zaret BL, Garner L, Bull MB, Fisherkeller M, Kosinski EJ, Krauthamer MJ, Maljanian R, McDowell AV, Sands MJ, Schwartz KV, Seltzer JP, Hager JD. The Connecticut Cardiovascular Consortium: a unique, state-wide research collaboration to advance clinical outcomes in patients with heart disease. Connecticut Medicine 2001, 65: 597-604. PMID: 11702518.Peer-Reviewed Original ResearchConceptsST-segment elevation acute myocardial infarctionPercutaneous coronary interventionClinical outcomesSegment elevation acute myocardial infarctionConnecticut residentsPatient careElevation acute myocardial infarctionUltimate clinical impactHealth care delivery modelsAcute myocardial infarctionCurrent health care policiesClinical outcome assessmentHealth care providersGood clinical practiceHealth care accessDifferent treatment patternsEvidence-based medicineHealth care policyMechanical reperfusionMechanical revascularizationPCI capabilityCoronary interventionFibrinolytic therapyTreatment patternsMyocardial infarction
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