2021
Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
de Oliveira K, Camilo C, Gastaldi V, Sant’Anna Feltrin A, Lisboa B, de Jesus Rodrigues de Paula V, Moretto A, Lafer B, Hoexter M, Miguel E, Maschietto M, Brentani H. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC Genomic Data 2021, 22: 45. PMID: 34717534, PMCID: PMC8557022, DOI: 10.1186/s12863-021-00993-0.Peer-Reviewed Original ResearchConceptsGene modulesMethylation changesBrain areasCpG sitesProtein-protein interaction networkDNA methylation modulationCommon transcriptional factorsDNA methylation changesSpecific signaling pathwaysGene expression dataOCD patientsPost-mortem brain tissueEpigenetic mechanismsInteraction networksMethylation modulationHypomethylation patternTranscriptional factorsEnvironmental risk factorsGene expressionBiological processesBackgroundObsessive–compulsive disorderSignaling pathwaysExpression dataG proteinsRisk factors
2016
Modulation of VEGF receptor 2 signaling by protein phosphatases
Corti F, Simons M. Modulation of VEGF receptor 2 signaling by protein phosphatases. Pharmacological Research 2016, 115: 107-123. PMID: 27888154, PMCID: PMC5205541, DOI: 10.1016/j.phrs.2016.11.022.Peer-Reviewed Original ResearchConceptsProtein phosphatasePhosphorylation of serineVascular endothelial growth factor receptor 2 signalingSignal transduction cascadePrecise biological roleSpecific signaling pathwaysKinase biologyEukaryotic cellsSignal terminatorRegulatory subunitPositive regulatorTransduction cascadePhosphorylation stateBiological roleContext of cancerParticular proteinDifferent proteinsGenome sequencingSignaling pathwaysVEGF receptor 2Receptor 2 signalingVEGF signalsProteinPhosphataseGenetic modelsIsolation and Culture of Adult Zebrafish Brain-derived Neurospheres.
Lopez-Ramirez MA, Calvo CF, Ristori E, Thomas JL, Nicoli S. Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres. Journal Of Visualized Experiments 2016, 53617. PMID: 26967835, PMCID: PMC4828210, DOI: 10.3791/53617.Peer-Reviewed Original ResearchConceptsAdult zebrafish brainStem/progenitor cellsZebrafish brainMolecular mechanismsRelevant model organismZebrafish adult brainProgenitor cellsSingle-cell dissociationSpecific signaling pathwaysAdult stem/progenitor cellsStem/progenitor cell proliferationNeural stem/progenitor cell proliferationProgenitor cell proliferationNeural stem/progenitor cellsModel organismsGene expressionCell dissociationSignaling pathwaysMultipotent neural stem/progenitor cellsNeurosphere assayAdult neurogenesisCell proliferationZebrafishBrain regenerationAdult brainDNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR
Micevic G, Muthusamy V, Damsky W, Theodosakis N, Liu X, Meeth K, Wingrove E, Santhanakrishnan M, Bosenberg M. DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR. Cell Reports 2016, 14: 2180-2192. PMID: 26923591, PMCID: PMC4785087, DOI: 10.1016/j.celrep.2016.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell Line, TumorCell ProliferationDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDown-RegulationGene Expression Regulation, NeoplasticHumansMechanistic Target of Rapamycin Complex 2Melanoma, ExperimentalMice, 129 StrainMice, Inbred C57BLMice, NudeMicroRNAsMultiprotein ComplexesNeoplasm TransplantationProportional Hazards ModelsRapamycin-Insensitive Companion of mTOR ProteinRNA InterferenceSkin NeoplasmsTOR Serine-Threonine KinasesTumor BurdenConceptsMelanoma formationPotential therapeutic targetMiR-196b expressionMouse melanoma modelPro-tumorigenic roleMTORC2 component RictorMelanoma growthTherapeutic targetMelanoma modelLoss of RictorHuman melanomaCancer typesTumor cellsMelanomaSpecific signaling pathwaysMTORC2 signalingSignaling pathwaysTurn preventsMiR-196b promoterDNA methyltransferase DNMT3BRictorControlling LevelsDNMT3BMethyltransferase DNMT3BCancer
2005
Oxygen-sensitive δ-Opioid Receptor-regulated Survival and Death Signals NOVEL INSIGHTS INTO NEURONAL PRECONDITIONING AND PROTECTION*
Ma M, Qian H, Ghassemi F, Zhao P, Xia Y. Oxygen-sensitive δ-Opioid Receptor-regulated Survival and Death Signals NOVEL INSIGHTS INTO NEURONAL PRECONDITIONING AND PROTECTION*. Journal Of Biological Chemistry 2005, 280: 16208-16218. PMID: 15687501, DOI: 10.1074/jbc.m408055200.Peer-Reviewed Original ResearchConceptsDelta-opioid receptorsHPC protectionSevere hypoxiaSpecific signaling pathwaysCytochrome c releaseP38 MAPK activityKinase C pathwayBcl-2 activityMembrane proteinsC releaseMAPK activityMolecular mechanismsSignaling pathwaysΔ-opioid receptorsP38 MAPKNovel insightsNovel mechanismC pathwayNeuronal injuryDOR antagonistDOR mRNAProtein levelsDOR expressionIschemic disordersNeuronal preconditioning
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