2024
Hox Genes
Duraiswamy A, Senkumar L, De Kumar B. Hox Genes. 2024 DOI: 10.1016/b978-0-12-822563-9.00196-7.Peer-Reviewed Original ResearchHox genesAberrant expression of HOX genesCell fate determinationExpression of Hox genesFate determinationTissue homeostasisMetastatic behavior of tumorsCell migrationGenesDevelopmental eventsDevelopmental defectsHoxCancer progressionAberrant expressionMetastatic behaviorBehavior of tumorsCellsDisease progressionDisease prognosisProteinHomeostasisOrganogenesisPrognosis
2022
Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum
Mitchel K, Bergmann JM, Brent AE, Finkelstein TM, Schindler KA, Holzman MA, Jeannotte L, Mansfield JH. Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum. Frontiers In Cell And Developmental Biology 2022, 10: 806545. PMID: 35557949, PMCID: PMC9086245, DOI: 10.3389/fcell.2022.806545.Peer-Reviewed Original ResearchLateral somitic frontierLateral plate mesodermSkeletal patterningTissue-specific contributionsPlate mesodermEmbryonic precursorsGenetic controlProper developmentHOXA5 expressionEmbryonic sourcesRegulate DevelopmentSkeletal phenotypeConditional deletionEmbryological informationMultiple rolesMesodermSkeletal systemHoxSomitesTheriansPrimordiaAdditive roleRegulatorDeletionMost aspects
2019
A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates
Parker H, De Kumar B, Green S, Prummel K, Hess C, Kaufman C, Mosimann C, Wiedemann L, Bronner M, Krumlauf R. A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Nature Communications 2019, 10: 1189. PMID: 30867425, PMCID: PMC6416258, DOI: 10.1038/s41467-019-09197-8.Peer-Reviewed Original ResearchConceptsNeural crestHox genesAncestral mechanismRegulatory circuitsUpstream regulatory componentsNeural crest patterningAncient paraloguesPbx proteinsJawed vertebratesAncient conservationExtant vertebratesAncestral activityRegulatory interactionsHOX2 genesRegulatory componentsVertebratesJaw formationGenesGnathostomesEnhancerHoxLampreyParaloguesImportant roleHoxa2
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