CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma
Xavier S, Nguyen V, Khairnar V, Phan A, Yang L, Nelson M, Shukla R, Wang J, Li A, Geng H, Lee J, Sadras T, Pham L, Weisenburger D, Chan W, Lang K, Shouse G, Danilov A, Song J, Parekh S, Müschen M, Ngo V. CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma. Nature Communications 2025, 16: 4967. PMID: 40436855, PMCID: PMC12120064, DOI: 10.1038/s41467-025-60208-3.Peer-Reviewed Original ResearchConceptsCarcinoembryonic antigen-related cell adhesion molecule 1B cell receptorB-cell receptor activationGenome-wide loss-of-function screensLoss-of-function screensB cell receptor complexMantle cell lymphomaF-actin cytoskeletonN-terminal ectodomainB-cell receptor signalingB cell receptor engagementSignal transduction studiesFilamin A.F-actinCytoplasmic tailMembrane microdomainsLipid raftsTransduction studiesCell lymphomaPathogenesis of mantle cell lymphomaReceptor signalingB cellsCell adhesion molecule 1Mantle cell lymphoma tumorsBCR-targeted therapies
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