2025
CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma
Xavier S, Nguyen V, Khairnar V, Phan A, Yang L, Nelson M, Shukla R, Wang J, Li A, Geng H, Lee J, Sadras T, Pham L, Weisenburger D, Chan W, Lang K, Shouse G, Danilov A, Song J, Parekh S, Müschen M, Ngo V. CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma. Nature Communications 2025, 16: 4967. PMID: 40436855, PMCID: PMC12120064, DOI: 10.1038/s41467-025-60208-3.Peer-Reviewed Original ResearchConceptsCarcinoembryonic antigen-related cell adhesion molecule 1B cell receptorB-cell receptor activationGenome-wide loss-of-function screensLoss-of-function screensB cell receptor complexMantle cell lymphomaF-actin cytoskeletonN-terminal ectodomainB-cell receptor signalingB cell receptor engagementSignal transduction studiesFilamin A.F-actinCytoplasmic tailMembrane microdomainsLipid raftsTransduction studiesCell lymphomaPathogenesis of mantle cell lymphomaReceptor signalingB cellsCell adhesion molecule 1Mantle cell lymphoma tumorsBCR-targeted therapiesPerturb-tracing enables high-content screening of multi-scale 3D genome regulators
Cheng Y, Hu M, Yang B, Jensen T, Zhang Y, Yang T, Yu R, Ma Z, Radda J, Jin S, Zang C, Wang S. Perturb-tracing enables high-content screening of multi-scale 3D genome regulators. Nature Methods 2025, 22: 950-961. PMID: 40211002, PMCID: PMC12074983, DOI: 10.1038/s41592-025-02652-z.Peer-Reviewed Original ResearchConceptsLoss-of-function screensPooled CRISPR screensIdentified new regulatorsGenome organizationChromatin domainsGenome regulationChromatin organizationChromosome territoriesChromatin tracingChromatin foldingChromatin topologyCRISPR screensHigh-content screeningChromatin compactionNuclear architectureLoop extrusionChromatinGenomic mechanismsHigh-content screening platformHuman cellsCompartmentalization mechanismFunctional linkTopological regulationGenomic effectsScreening platform
2023
Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition
Xie Y, Wang Q, Yang Y, Near D, Wang H, Colon M, Nguyen C, Slattery C, Keepers B, Farber G, Wang T, Lee S, Ian Shih Y, Liu J, Qian L. Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition. Nature Cardiovascular Research 2023, 2: 1060-1077. PMID: 38524149, PMCID: PMC10959502, DOI: 10.1038/s44161-023-00344-5.Peer-Reviewed Original ResearchTranslational regulationTranslational landscapeLayer of regulatory mechanismLoss-of-function screensY-box binding protein 1ICM reprogrammingBinding protein 1Induced cardiomyocytes generationFate acquisitionInduced cardiomyocytesEpigenetic mechanismsTranscriptome profilingTranslational levelY-boxRegulatory mechanismsYBX1Reprogramming of fibroblastsReprogrammingDirect reprogramming of fibroblastsCardiac reprogrammingProtein 1Mouse model of myocardial infarctionReduced scar sizeDirect reprogrammingModel of myocardial infarction
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