2023
Rhesus macaque Bcl-6/Bcl-xL B cell immortalization: Discovery of HIV-1 neutralizing antibodies from lymph node
Samsel J, Boswell K, Watkins T, Ambrozak D, Mason R, Yamamoto T, Ko S, Yang Y, Zhou T, Doria-Rose N, Foulds K, Roederer M, Mascola J, Kwong P, Gama L, Koup R. Rhesus macaque Bcl-6/Bcl-xL B cell immortalization: Discovery of HIV-1 neutralizing antibodies from lymph node. Journal Of Immunological Methods 2023, 516: 113445. PMID: 36848985, DOI: 10.1016/j.jim.2023.113445.Peer-Reviewed Original ResearchConceptsB cellsLymph nodesRhesus macaquesHIV-1HIV-1 vaccineExpression of CD40Surface B-cell receptorB-cell immortalizationPre-clinical testingB cell receptorIL-21CD40 ligandAntigen specificityBCL-6Cell receptorIdentification of cellsAntibodiesFunctional assaysCell immortalizationBcl-xLAntigen probeCellsRetroviral vectorsSomatic hypermutationAntibody discovery
2022
Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings
Boswell K, Watkins T, Cale E, Samsel J, Andrews S, Ambrozak D, Driscoll J, Messina M, Narpala S, Hopp C, Cagigi A, Casazza J, Yamamoto T, Zhou T, Schief W, Crompton P, Ledgerwood J, Connors M, Gama L, Kwong P, McDermott A, Mascola J, Koup R. Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings. Frontiers In Immunology 2022, 13: 1087018. PMID: 36582240, PMCID: PMC9794141, DOI: 10.3389/fimmu.2022.1087018.Peer-Reviewed Original ResearchConceptsB cell subsetsB cell clonesB-cell immortalizationMemory B cellsB cellsCell subsetsCell clonesHIV-1 infected individualsMemory B cell subsetsDifferent B cell populationsIsolation of antibodiesRecent malaria infectionFuture vaccine designCell immortalizationB cell populationsB cell survivalMalaria infectionPrimary B cellsVaccine settingInfection settingsImmunoglobulin secretionHealthy individualsTonsil tissueAntibody secretionBCL-6
2014
Insights into the Role of Follicular Helper T Cells in Autoimmunity
Park H, Kim D, Lim S, Kim W, Youn J, Choi Y, Choi J. Insights into the Role of Follicular Helper T Cells in Autoimmunity. Immune Network 2014, 14: 21-29. PMID: 24605077, PMCID: PMC3942504, DOI: 10.4110/in.2014.14.1.21.Peer-Reviewed Original ResearchTfh cell differentiationFollicular helper T cellsTfh cellsSystemic lupus erythematosusHelper T cellsT cellsAutoimmune diseasesB cellsBcl-6 expressionRheumatoid arthritisGerminal centersBCL-6Follicular regulatory T cellsB cell folliclesRegulatory T cellsNaïve T cellsMemory B cellsSurface moleculesCell differentiationImportant surface moleculesTfr cellsTreg cellsIL-21Lupus erythematosusPD-1
2013
Follicular T‐helper cells: controlled localization and cellular interactions
Qi H, Chen X, Chu C, Lu P, Xu H, Yan J. Follicular T‐helper cells: controlled localization and cellular interactions. Immunology And Cell Biology 2013, 92: 28-33. PMID: 24145857, DOI: 10.1038/icb.2013.59.Peer-Reviewed Original ResearchConceptsB cell responsesGerminal centersTfh cellsEffective antibody-based vaccineFollicular T helper cellsDependent B cell responsesIsotype-switched antibodiesAntibody-based vaccinesCD4 T cellsT helper cellsHumoral autoimmunityHumoral protectionT cellsTranscriptional repressor Bcl-6Surface phenotypeSuch antibodiesBCL-6Microbial infectionsGC reactionAntibodiesCellsCellular interactionsCurrent understandingHigh levelsAutoimmunityGerminal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells
Park H, Kim D, Choi J. Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells. Hanyang Medical Reviews 2013, 33: 10-16. DOI: 10.7599/hmr.2013.33.1.10.Peer-Reviewed Original ResearchFollicular helper T cellsFollicular regulatory T cellsGerminal center reactionRegulatory T cellsHelper T cellsT cell helpT cellsB cellsCenter reactionAutoimmune diseasesCell helpT-betBCL-6Antigen-specific T cellsTranscription factor Bcl-6Expression of CXCR5B cell folliclesPeripheral tolerance mechanismsCD4 T cellsMemory B cellsGerminal center formationIsotype class switchingTfh populationTh17 cellsTfh differentiation
2012
IL-10-IL-21-STAT3 axis regulates memory CD8 T cell development (110.9)
Cui W, Liu Y, Weinstein J, Craft J, Kaech S. IL-10-IL-21-STAT3 axis regulates memory CD8 T cell development (110.9). The Journal Of Immunology 2012, 188: 110.9-110.9. DOI: 10.4049/jimmunol.188.supp.110.9.Peer-Reviewed Original ResearchCD8 T cellsMemory T cellsMemory CD8 T cell developmentMemory CD8 T cellsCD8 T cell developmentT cellsT cell developmentIL-21IL-10Virus-specific CD8 T cellsBCL-6Effector CD8 T cellsProtective memory T cellsCentral memory T cellsMemory CD8 T cell differentiationCD8 T cell differentiationAcute LCMV infectionMemory precursor cellsCell developmentMemory cell developmentSTAT3-SOCS3 pathwayT cell differentiationAcute infectionLCMV infectionIL-12
2011
An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells. Immunity 2011, 35: 792-805. PMID: 22118527, PMCID: PMC3431922, DOI: 10.1016/j.immuni.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell DifferentiationGene Expression Regulation, DevelopmentalImmunologic MemoryInterleukin-10InterleukinsMiceMice, KnockoutPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-bcl-6Signal TransductionSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsT-Box Domain ProteinsTranscription FactorsConceptsMemory T cellsT cellsBCL-6Protective memory T cellsCentral memory T cellsSTAT3 pathwayAcute LCMV infectionExpression of EomesLong-term immunityMemory precursor cellsSTAT3-SOCS3 pathwayMemory cell developmentCell developmentT cell developmentMemory CD8IL-21LCMV infectionIL-12Interleukin-10Inflammatory cytokinesFunctional maturationSOCS3 expressionBlimp-1Precursor cellsSTAT3Inter-follicular germinal center B cell and T follicular helper cell development precedes follicular Tfh maintenance (63.23)
Kerfoot S, Yaari G, Patel J, Johnson K, Gonzalez D, Kleinstein S, Haberman A. Inter-follicular germinal center B cell and T follicular helper cell development precedes follicular Tfh maintenance (63.23). The Journal Of Immunology 2011, 186: 63.23-63.23. DOI: 10.4049/jimmunol.186.supp.63.23.Peer-Reviewed Original ResearchGerminal center B cellsB cellsPD-1T cellsT-cell immigrationFollicular helper cell developmentTfh cell differentiationCognate B cellsDays post immunizationSuch B cellsB cell entryTfh cellsTFH phenotypeInterfollicular zonesPost immunizationGerminal centersBCL-6GL7 expressionCell immigrationLong-term maintenanceCell entryCell developmentFolliclesCell typesCellsCharacterization of different subsets of human follicular helper T (TFH) cells (152.9)
Choi J, Kim S, Lainez B, Craft J. Characterization of different subsets of human follicular helper T (TFH) cells (152.9). The Journal Of Immunology 2011, 186: 152.9-152.9. DOI: 10.4049/jimmunol.186.supp.152.9.Peer-Reviewed Original ResearchFollicular helper T cellsB cell folliclesHelper T cellsTfh cellsT cellsIL-21P-selectin glycoprotein ligand-1IL-4Germinal centersB cellsTonsillar Tfh cellsIL-17 secretionExpression of CD127B cell helpAntigen-specific antibodiesGC B cellsTh17 cellsTfh subsetsPD-1Effector subsetsCell helpTherapeutic targetBCL-6RORC expressionHuman tonsils
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