2017
Integrins, Immunology
de Moll E, Dong J, Oliva M, Saenger Y. Integrins, Immunology. 2017, 285-294. DOI: 10.1007/978-1-4419-0717-2_131.Peer-Reviewed Original ResearchSuccessful human trialsAnti-integrin antibodiesIntegrin blockadeClinical trialsHuman trialsRole of integrinsPrincipal receptorTumor growthTumor proliferationTumor cellsMetastasisIntegrin expressionCell functionExtracellular matrix proteinsMultiple mechanismsTrialsAngiogenesisIntegrinsMatrix proteinsProliferationCell signalingMajor roleBlockade
2016
Integrins, Immunology
de Moll E, Dong J, Oliva M, Saenger Y. Integrins, Immunology. 2016, 1-10. DOI: 10.1007/978-1-4614-6613-0_131-2.Peer-Reviewed Original ResearchSuccessful human trialsAnti-integrin antibodiesIntegrin blockadeClinical trialsHuman trialsRole of integrinsPrincipal receptorTumor growthTumor proliferationTumor cellsMetastasisIntegrin expressionCell functionExtracellular matrix proteinsMultiple mechanismsTrialsAngiogenesisIntegrinsMatrix proteinsProliferationCell signalingMajor roleBlockade
2014
Integrins, Immunology
de Moll E, Dong J, Oliva M, Saenger Y. Integrins, Immunology. 2014, 1-9. DOI: 10.1007/978-1-4614-6613-0_131-1.Peer-Reviewed Original ResearchSuccessful human trialsAnti-integrin antibodiesIntegrin blockadeClinical trialsHuman trialsRole of integrinsPrincipal receptorTumor growthTumor proliferationTumor cellsMetastasisIntegrin expressionCell functionExtracellular matrix proteinsMultiple mechanismsTrialsAngiogenesisIntegrinsMatrix proteinsProliferationCell signalingMajor roleBlockade
2010
Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility
Martinez-Rico C, Pincet F, Thiery JP, Dufour S. Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility. Journal Of Cell Science 2010, 123: 712-722. PMID: 20144995, DOI: 10.1242/jcs.047878.Peer-Reviewed Original ResearchConceptsIntercellular adhesionActomyosin contractilityCell doubletsE-cadherin-mediated intercellular adhesionIntercellular adhesion strengthSrc family kinasesCell-matrix interactionsSrc kinase activationExistence of crosstalkRole of integrinsFamily kinasesCadherin-7Cell plasticityMolecular crosstalkMajor adhesion moleculeIntegrin stimulationCell spreadingCadherinCell adhesionII activityIntegrinsPolylysine-coated beadsAdhesion moleculesCrosstalkAdhesion
2006
Integrins in the Ovary
Monniaux D, Huet-Calderwood C, Bellego F, Fabre S, Monget P, Calderwood D. Integrins in the Ovary. Seminars In Reproductive Medicine 2006, 24: 251-261. PMID: 16944422, DOI: 10.1055/s-2006-948554.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRole of integrinsSperm ADAMsActin cytoskeletonExtracellular matrix componentsIntegrin tailsMultiple signalingOocyte integrinsOvarian surface epithelium cellsIntegrin functionConformational changesExtracellular matrixIntegrinsCell proliferationMatrix componentsTumor developmentMajor receptorIntegrin expressionSurface epithelium cellsPossible involvementPotential roleFollicular cellsGranulosa cellsCellsFollicular basement membraneEpithelium cells
2005
Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*
Katsumi A, Naoe T, Matsushita T, Kaibuchi K, Schwartz MA. Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*. Journal Of Biological Chemistry 2005, 280: 16546-16549. PMID: 15760908, DOI: 10.1074/jbc.c400455200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionEnzyme ActivationEnzyme InhibitorsExtracellular MatrixExtracellular Signal-Regulated MAP KinasesIntegrin alphaVbeta3IntegrinsJNK Mitogen-Activated Protein KinasesLigandsMAP Kinase Kinase 4MiceMitogen-Activated Protein Kinase KinasesNIH 3T3 CellsPhosphatidylinositol 3-KinasesPhosphorylationProtein ConformationSignal TransductionStress, MechanicalTime FactorsConceptsIntegrin activationExtracellular matrix proteinsRole of integrinsConformational activationBiochemical signalsNIH3T3 cellsMolecular mechanismsCellular responsesMatrix proteinsExtracellular matrixCell growthMechanical stretch stimulationIntegrin alphavbeta3IntegrinsMechanical tensionMechanical stretchCritical determinantStretch stimulationActivationPhosphoinositolMechanotransductionJNKProteinApoptosisDifferentiation
2004
Integrins in Mechanotransduction*
Katsumi A, Orr AW, Tzima E, Schwartz MA. Integrins in Mechanotransduction*. Journal Of Biological Chemistry 2004, 279: 12001-12004. PMID: 14960578, DOI: 10.1074/jbc.r300038200.Peer-Reviewed Original Research
1994
Integrins as Signal Transducing Receptors
Schwartz M. Integrins as Signal Transducing Receptors. 1994, 33-47. DOI: 10.1016/b978-0-08-091729-0.50007-3.Peer-Reviewed Original ResearchSignal transducing receptorsExtracellular matrixProtein kinase CCell functionIntracellular second messengerRole of integrinsCytoskeletal organizationInositol lipidsCell shapeSecond messengerKinase CAnchorage-dependent cellsSuch messengersCell typesContact of cellsOnly adhesionIntegrinsMessengerActivation of plateletsCellsCytoskeletonRecent dataReceptorsAdhesionDifferentiation
1991
Vitronectin and thrombospondin promote retinal neurite outgrowth: Developmental regulation and role of integrins
Neugebauer K, Emmett C, Venstrom K, Reichardt L. Vitronectin and thrombospondin promote retinal neurite outgrowth: Developmental regulation and role of integrins. Neuron 1991, 6: 345-358. PMID: 1705807, DOI: 10.1016/0896-6273(91)90244-t.Peer-Reviewed Original ResearchConceptsRetinal neuronsEmbryonic chick retinal neuronsChick retinal neuronsNeurite outgrowthNeurite outgrowth-promoting moleculesRetinal neurite outgrowthBeta 1 subunitRole of integrinsAxonal growthAlpha vSpecific receptorsRetinal developmentNeuronal developmentExtracellular matrix glycoproteinNeuronsReceptorsNeuroretinaThrombospondinMatrix glycoproteinGlycoproteinVitronectin
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