2025
Structural insights into RNA targeting with de novo small molecule
Xu L, Chung K, Liu T, Pyle A. Structural insights into RNA targeting with de novo small molecule. Structural Dynamics 2025, 12: a41-a41. DOI: 10.1063/4.0000350.Peer-Reviewed Original ResearchRNA-small molecule interactionsChemical space explorationRNA-ligand recognitionMedicinal chemistry campaignHigh-throughput screening assayChemistry campaignSelf-splicing intronsInhibitor discoveryNon-coding genesMolecule interactionsCryo-EM structureSmall moleculesAtomic detailRNA bindersStructural insightsMolecular interactionsC. albicansTarget RNASplicing inhibitorsGene productsRNA moleculesRNA targetsDruggable genomeDrug developmentMolecules
2024
Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide
Moon M, Vock I, Streit A, Connor L, Senkina J, Ellman J, Simon M. Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide. ACS Chemical Biology 2024, 19: 2081-2086. PMID: 39192734, PMCID: PMC11683664, DOI: 10.1021/acschembio.4c00538.Peer-Reviewed Original ResearchCytochrome c oxidase 1Binding sitesRNA-small molecule interactionsPotential binding sitesTranscriptome-wide screeningSmall molecule disulfideSpinal muscular atrophyCellular RNARNA sitesTarget RNAMetabolic labelingSmall molecule bindingRNADisulfide analoguesLead moleculesMolecule bindingTranscriptomeFDA-approved drugsStructural probesMolecule interactionsCovalent attachmentDisulfide tetherThermodynamic propertiesTreat spinal muscular atrophyDisulfide
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