2013
Defining the functional determinants for RNA surveillance by RIG‐I
Kohlway A, Luo D, Rawling DC, Ding SC, Pyle AM. Defining the functional determinants for RNA surveillance by RIG‐I. EMBO Reports 2013, 14: 772-779. PMID: 23897087, PMCID: PMC3790051, DOI: 10.1038/embor.2013.108.Peer-Reviewed Original ResearchConceptsMelanoma differentiation-associated gene 5Robust ATPase activityDuplex RNA substrateMinimal functional unitATPase activityRetinoic acid-inducible geneInnate immune machineryAcid-inducible geneRNA surveillanceDifferentiation-associated gene 5RNA substratesIntracellular RNA sensorsDuplex RNARNA complexRNA targetsGene 5RNA virusesDistinct conformationsRNA sensorsDsRNA complexImmune machineryRNA duplexesInterferon responseFunctional determinantsFunctional units
2009
Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses
Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB. Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses. The Journal Of Immunology 2009, 183: 6989-6997. PMID: 19890046, PMCID: PMC2920602, DOI: 10.4049/jimmunol.0901386.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell LineDEAD Box Protein 58DEAD-box RNA HelicasesEpithelial CellsGene ExpressionHumansInterferon-Induced Helicase, IFIH1Picornaviridae InfectionsReceptors, ImmunologicReceptors, Pattern RecognitionRespiratory MucosaReverse Transcriptase Polymerase Chain ReactionRhinovirusRNA, Double-StrandedRNA, Small InterferingSignal TransductionToll-Like Receptor 3ConceptsIL-8/CXCL8RV-1BChronic obstructive pulmonary disease exacerbationsObstructive pulmonary disease exacerbationsGM-CSFMelanoma differentiation-associated geneAirway epithelial cell responsesIFN-lambda1Pulmonary disease exacerbationsBEAS-2B human bronchial epithelial cellsRetinoic acid-inducible geneToll/IL-1RHuman bronchial epithelial cellsPattern recognition receptorsEpithelial cell responsesUV-irradiated virusBronchial epithelial cellsAcid-inducible geneBEAS-2B cellsDisease exacerbationTLR-3IFN response factorsCommon coldIL-1RIFN expression
2008
Innate sensors of influenza virus: clues to developing better intranasal vaccines
Ichinohe T, Iwasaki A, Hasegawa H. Innate sensors of influenza virus: clues to developing better intranasal vaccines. Expert Review Of Vaccines 2008, 7: 1435-1445. PMID: 18980544, PMCID: PMC2724183, DOI: 10.1586/14760584.7.9.1435.Peer-Reviewed Original ResearchConceptsInfluenza vaccineInnate sensorsVirus infectionImmune systemInfluenza virusIntranasal influenza vaccineVariant virus infectionNatural infectionEffective influenza vaccinesInfluenza virus infectionToll-like receptorsRetinoic acid-inducible geneNOD-like receptorsInnate immune systemPattern recognition receptorsAdaptive immune systemAcid-inducible geneParenteral immunizationIntranasal vaccineMucosal immunitySystemic immunityInactivated vaccinesRespiratory tractAdaptive immunityLike receptors
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