2022
2348. Distinct cerebrospinal fluid immune proteins mark neurosyphilis
Catalano A, Yoon J, Farhadian S, Fertuzinhos S, Gisslen M, Zetterberg H, Marra C, Walsh H. 2348. Distinct cerebrospinal fluid immune proteins mark neurosyphilis. Open Forum Infectious Diseases 2022, 9: ofac492.155. DOI: 10.1093/ofid/ofac492.155.Peer-Reviewed Original ResearchHIV statusImmune responseBCA-1/CXCL13Macrophage/microglial activationIP-10/CXCL10IL-8/CXCL8CNS immune responseNeuronal injury markersNon-NS groupPotential CSF biomarkersMIG/CXCL9Date of enrollmentHigh-sensitivity ELISAWilcoxon rank sum testSpecific immune pathwaysMultiple comparisonsRank sum testRace/ethnicityCNS inflammationMicroglial activationCSF WBCElevated markersInjury markersNeuronal damageAsymptomatic diseaseMacrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells
Kantrong N, Chang AM, Bamashmous S, Hajjar AM, Bucala RJ, Darveau RP. Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells. The Journal Of Periodontology 2022, 93: 1940-1950. PMID: 35100435, DOI: 10.1002/jper.21-0598.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorGingival epithelial cellsIL-8/CXCL8Migration inhibitory factorGingival tissuesJunctional epitheliumGingival epitheliumRole of MIFInhibitory factorMIF KO miceEpithelial cellsExpression of TLR4Healthy gingival tissuesToll-like receptorsInterleukin-1 receptorRepertoire of receptorsOral healthNeutrophil chemoattractantIL-1R1IL-1R2Neutrophil regulationKO micePeriodontal tissuesIL-1ROral homeostasis
2009
Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses
Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB. Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses. The Journal Of Immunology 2009, 183: 6989-6997. PMID: 19890046, PMCID: PMC2920602, DOI: 10.4049/jimmunol.0901386.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell LineDEAD Box Protein 58DEAD-box RNA HelicasesEpithelial CellsGene ExpressionHumansInterferon-Induced Helicase, IFIH1Picornaviridae InfectionsReceptors, ImmunologicReceptors, Pattern RecognitionRespiratory MucosaReverse Transcriptase Polymerase Chain ReactionRhinovirusRNA, Double-StrandedRNA, Small InterferingSignal TransductionToll-Like Receptor 3ConceptsIL-8/CXCL8RV-1BChronic obstructive pulmonary disease exacerbationsObstructive pulmonary disease exacerbationsGM-CSFMelanoma differentiation-associated geneAirway epithelial cell responsesIFN-lambda1Pulmonary disease exacerbationsBEAS-2B human bronchial epithelial cellsRetinoic acid-inducible geneToll/IL-1RHuman bronchial epithelial cellsPattern recognition receptorsEpithelial cell responsesUV-irradiated virusBronchial epithelial cellsAcid-inducible geneBEAS-2B cellsDisease exacerbationTLR-3IFN response factorsCommon coldIL-1RIFN expression
2006
Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity
Iwata M, Pillai M, Ramakrishnan A, Hackman R, Deeg H, Opdenakker G, Torok-Storb B. Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity. Blood 2006, 109: 85-92. PMID: 16954500, PMCID: PMC1785081, DOI: 10.1182/blood-2006-05-020289.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBone MarrowCells, CulturedChemokinesCulture Media, ConditionedCytokinesEnzyme InductionFemaleFibroblastsHumansIn Situ Hybridization, FluorescenceLipopolysaccharide ReceptorsMaleMatrix Metalloproteinase 9Middle AgedMonocytesMyelodysplastic SyndromesRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStromal CellsConceptsMMP-9Myelodysplastic syndromeMarrow cellularityMonocyte populationsMatrix metalloproteinasesGelatinase B/matrix metalloproteinase-9Stromal cellsMCP-1/CCL2IL-8/CXCL8SDF-1/CXCL12Matrix metalloproteinase-9MMP-9 expressionMarker-positive cellsInducible levelsMDS patientsIL-6Healthy donorsMetalloproteinase-9Marrow stromal cellsG-CSFPatientsGM-CSFMonocytesStromal factorsM-CSF
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