2022
Impact of hyperthermic intraperitoneal chemotherapy on genomic heterogeneity of peritoneal metastases in stage IV gastroesophageal adenocarcinoma.
Sood D, Fefferman M, Reizine N, Morgan R, Ong C, Dhiman A, Turaga K, Catenacci D, Eng O. Impact of hyperthermic intraperitoneal chemotherapy on genomic heterogeneity of peritoneal metastases in stage IV gastroesophageal adenocarcinoma. Journal Of Clinical Oncology 2022, 40: 312-312. DOI: 10.1200/jco.2022.40.4_suppl.312.Peer-Reviewed Original ResearchHyperthermic intraperitoneal chemotherapyTumor mutational burdenLaparoscopic hyperthermic intraperitoneal chemotherapyTumor mutation burden levelPD-L1 statusPD-L1 expressionPD-L1Gastroesophageal adenocarcinomaPeritoneal metastasisOverall survivalSystemic chemotherapyIntraperitoneal chemotherapyImpact of hyperthermic intraperitoneal chemotherapyEffect of hyperthermic intraperitoneal chemotherapyMedian peritoneal cancer indexResponse to systemic chemotherapyProgrammed death-ligand 1Genomic heterogeneityMedian overall survivalPeritoneal cancer indexTemporal genomic heterogeneityDeath-ligand 1Response to therapyDatabase of patientsTumor suppressor gene
2021
Patterns of peritoneal dissemination and response to systemic chemotherapy in common and rare peritoneal tumours treated by cytoreductive surgery: study protocol of a prospective, multicentre, observational study
Bhatt A, Rousset P, Baratti D, Biacchi D, Benzerdjeb N, de Hingh I, Deraco M, Gushchin V, Kammar P, Labow D, Levine E, Moran B, Mohamed F, Morris D, Mehta S, Nissan A, Alyami M, Adileh M, Barat S, Yacov A, Campbell K, Cummins-Perry K, Cortes-Guiral D, Cohen N, Parikh L, Alammari S, Bashanfer G, Alshukami A, Kundalia K, Goswami G, van de Vlasakker V, Sittig M, Sammartino P, Sardi A, Villeneuve L, Turaga K, Yonemura Y, Glehen O. Patterns of peritoneal dissemination and response to systemic chemotherapy in common and rare peritoneal tumours treated by cytoreductive surgery: study protocol of a prospective, multicentre, observational study. BMJ Open 2021, 11: e046819. PMID: 34226220, PMCID: PMC8258594, DOI: 10.1136/bmjopen-2020-046819.Peer-Reviewed Original ResearchConceptsPeritoneal cancer indexResponse to systemic chemotherapyCytoreductive surgerySystemic chemotherapyPeritoneal metastasisRadiological predictorsBiopsy-proven PMCompleteness of cytoreductionRare peritoneal tumorsRegional node involvementOptimal patient selectionLymph node metastasisStudy protocolProgression-FreeNode involvementPeritoneal disseminationPeritoneal resectionPeritoneal tumorsOverall survivalPrognostic factorsCancer indexPeritoneal mesotheliomaTumor gradeOvarian cancerTumor nodules
2016
Hyperthermic Intraperitoneal Chemotherapy and Cytoreductive Surgery in the Management of Peritoneal Carcinomatosis
Rajeev R, Turaga K. Hyperthermic Intraperitoneal Chemotherapy and Cytoreductive Surgery in the Management of Peritoneal Carcinomatosis. Cancer Control 2016, 23: 36-46. PMID: 27009455, DOI: 10.1177/107327481602300107.Peer-Reviewed Original ResearchConceptsPeritoneal diseaseIntraperitoneal chemotherapyPoor response to systemic chemotherapyCytoreductive surgery/hyperthermic intraperitoneal chemotherapyManagement of peritoneal diseaseResponse to systemic chemotherapyManagement of peritoneal carcinomatosisApplication of laparoscopic techniquesMalignant peritoneal diseaseHyperthermic intraperitoneal chemotherapySignificant survival gainsCohort of patientsAppropriate patient selectionVascularization of tumorsCytoreductive proceduresCytoreductive surgeryPeritoneal carcinomatosisSystemic chemotherapyCytoreductive techniquesPrognostic scoreCancer cachexiaLaparoscopic techniquePatient selectionBowel obstructionSurvival gain
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