2023
Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function
Lei I, Huang W, Noly P, Naik S, Ghali M, Liu L, Pagani F, Abou El Ela A, Pober J, Pitt B, Platt J, Cascalho M, Wang Z, Chen Y, Mortensen R, Tang P. Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function. Science Translational Medicine 2023, 15: eade3782. PMID: 36753565, PMCID: PMC10068866, DOI: 10.1126/scitranslmed.ade3782.Peer-Reviewed Original ResearchConceptsImmune response gene 1Primary graft dysfunctionDonor heart preservationValproic acidDonor heartsVPA treatmentHeart preservationHeart functionImmune-responsive gene 1Donor heart functionHistone deacetylase inhibitor valproic acidImproved heart functionAntioxidant protein expressionMetabolic reprogrammingDonor-recipient matchingPromising therapeutic strategyHuman donor heartsInhibitor valproic acidGene 1Graft dysfunctionCardioprotective effectsKetoglutarate solutionTherapeutic strategiesResponse gene-1Nuclear factor
2004
Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis
Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis. Journal Of Experimental Medicine 2004, 200: 377-389. PMID: 15289506, PMCID: PMC2211975, DOI: 10.1084/jem.20040104.Peer-Reviewed Original ResearchConceptsVivo effector functionGrowth factor-β1Early growth response gene-1Pulmonary fibrosisSeptal rupturePulmonary disordersInterstitial diseaseEffector functionsFibrotic responseMurine lungTissue fibrosisEpithelial apoptosisFactor-β1Alveolar remodelingResponse gene-1FibrosisBioactive TGFTGFMyocyte hyperplasiaGrowth factorEarly growth response geneApoptosisLungPathogenesisGene 1
1994
Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene‐1 by arginine vasopressin in rat mesangial cells
Rupprecht H, Sukhatme V, Rupprecht A, Sterzel R, Coleman D. Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene‐1 by arginine vasopressin in rat mesangial cells. Journal Of Cellular Physiology 1994, 159: 311-323. PMID: 8163570, DOI: 10.1002/jcp.1041590214.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArginine VasopressinBase SequenceBloodDNA-Binding ProteinsEarly Growth Response Protein 1Enzyme ActivationGene Expression RegulationGlomerular MesangiumHalf-LifeImmediate-Early ProteinsMolecular Sequence DataPromoter Regions, GeneticProtein Kinase CRatsRNA, MessengerTranscription FactorsTranscription, GeneticConceptsEarly growth response gene-1Transcriptional inductionResponse gene-1Egr-1Gene 1Electrophoretic mobility shift assaysDependent transcriptional inductionDNA-protein interactionsPromoter deletion analysisMobility shift assaysIntracellular biochemical eventsProtein kinase CInduction of mitogenesisMesangial cellsEarly gene expressionExtracellular matrix productionDeletion analysisPK CShift assaysTranscriptional levelAVP stimulationHeterologous promoterConsensus sequenceGene expressionPromoter activityAnalysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor.
Li C, Mitchell D, Coleman D. Analysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor. The Yale Journal Of Biology And Medicine 1994, 67: 269-76. PMID: 8579643, PMCID: PMC2588905.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, WesternCell DivisionDNA-Binding ProteinsDose-Response Relationship, DrugEarly Growth Response Protein 1Granulocyte-Macrophage Colony-Stimulating FactorImmediate-Early ProteinsMacrophages, PeritonealMiceMolecular Sequence DataThioglycolatesTranscription FactorsConceptsEgr-1 proteinMurine peritoneal macrophagesEarly growth response gene-1Macrophage proliferationGranulocyte-macrophage colony-stimulating factorResponse gene-1Egr-1 mRNAProtein speciesColony-stimulating factorGM-CSFPathogen invasionWestern blot analysisGene 1Stimulation of macrophagesMacrophage differentiationPeritoneal macrophagesProtein inductionProteinBlot analysisTranscriptionProliferationGM-CSF inductionInductionMacrophagesPhysiologic circumstances
1993
PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements
Rupprecht H, Sukhatme V, Lacy J, Sterzel R, Coleman D. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. American Journal Of Physiology 1993, 265: f351-f360. PMID: 8214093, DOI: 10.1152/ajprenal.1993.265.3.f351.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA-Binding ProteinsEarly Growth Response Protein 1Gene ExpressionGlomerular MesangiumImmediate-Early ProteinsMolecular Sequence DataNuclear ProteinsOligonucleotide ProbesPhosphorylationPlatelet-Derived Growth FactorPromoter Regions, GeneticRatsSerum Response FactorTranscription FactorsTranscription, GeneticTyrosineConceptsPlatelet-derived growth factorPDGF stimulationElectrophoretic mobility shift assaysNuclear run-off assaysPromoter deletion analysisEgr-1 transcriptionEarly growth response gene-1Serum response elementUpstream serum response elementsProtein tyrosine phosphorylationMobility shift assaysRun-off assaysResponse gene-1Egr-1 inductionEgr-1 mRNAEgr-1 expressionImmediate early genesTranscriptional inductionDeletion analysisTyrosine phosphorylationShift assaysTranscriptional levelConsensus sequenceTranscription rateGene expression
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