Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41
Maslennikova A, Kruglova N, Kalinichenko S, Komkov D, Shepelev M, Golubev D, Siniavin A, Vzorov A, Filatov A, Mazurov D. Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41. MBio 2022, 13: e03589-21. PMID: 35073736, PMCID: PMC8787484, DOI: 10.1128/mbio.03589-21.Peer-Reviewed Original ResearchConceptsHIV-1 infectionCD4 lymphocytesHIV-1Antiretroviral therapyLentiviral vectorsT cellsHeptad repeat 2Resistance to HIV-1 infectionTherapy of HIV infectionInhibitors of HIV-1 entryHIV-1 proviral DNATherapeutic lentiviral vectorInhibitors of HIV-1 fusionHIV-1 entryKnock-inCell surfaceT cell linesHIV-1 fusionProtection of lymphocytesKnock-in (KIGene modificationLatent provirusesHIV infectionViral clearanceFusion inhibitory peptides
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