Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity
Sun S, Levenstein D, Li B, Mandelberg N, Chenouard N, Suutari B, Sanchez S, Tian G, Rinzel J, Buzsáki G, Tsien R. Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity. Cell Reports 2024, 43: 113839. PMID: 38507409, PMCID: PMC12131992, DOI: 10.1016/j.celrep.2024.113839.Peer-Reviewed Original ResearchConceptsLong-term depressionLong-term potentiationSynaptic homeostasisPostsynaptic glutamate receptorsNeuronal inactivityNervous system functionGlutamate receptorsSynaptic adaptationHomeostatic changesHebbian mechanismsSynaptic plasticitySynaptic scalingRegulation of synapsesHomeostatic scalingMultiphasic responseHomeostatic regulationNeurological conditionsSynapsesSystem functionHomeostasisCaMKIICalcineurinInactivity
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