2022
The role of alcohol intake in the pharmacogenetics of treatment with clozapine
Monroy-Jaramillo N, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Montalvo-Ortiz J, López-López M. The role of alcohol intake in the pharmacogenetics of treatment with clozapine. Pharmacogenomics 2022, 23: 371-392. PMID: 35311547, DOI: 10.2217/pgs-2022-0006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdverse reactionsAlcohol intakeConcomitant useSevere adverse reactionsGood therapeutic effectPrecision medicine approachRefractory psychosisAtypical antipsychoticsInterindividual responseTherapeutic effectClozapineMedicine approachPharmacogenetic studiesSignificant riskIntakePatientsGenetic variantsPharmacogeneticsAntipsychoticsPsychosisCYP1A2Receptors
2021
Integrative Genomic–Epigenomic Analysis of Clozapine-Treated Patients with Refractory Psychosis
Mayén-Lobo YG, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Genis-Mendoza AD, de Montellano D, Soto-Reyes E, Nicolini H, López-López M, Monroy-Jaramillo N. Integrative Genomic–Epigenomic Analysis of Clozapine-Treated Patients with Refractory Psychosis. Pharmaceuticals 2021, 14: 118. PMID: 33557049, PMCID: PMC7913835, DOI: 10.3390/ph14020118.Peer-Reviewed Original ResearchRefractory psychosisPolygenic risk scoresMood stabilizersMetabolic ratioOnly antipsychotic drugUse of clozapineEffective mood stabilizerCLZ treatmentAntipsychotic drugsRisk scoreClozapineBipolar disorderLarger sample sizePatientsPsychosisGABAergic synapse pathwayBD-PRSFuture studiesSample sizeHigh-impact variantsAntipsychoticsPathwayFindingsMethylome profilesComplex mechanisms
2019
On Neuropsychiatric Manifestations of Basal Ganglia Injury: A Report of Three Cases and Literature Review
Azizi H, Kilpatrick A, Olayinka O, Poopola O, Ahmad M, Kahn A, Khan T, Rimawi D, Williams S, Jayaraj S, Leung I, Langdon S, Iskander M, Chohan A, Nuthalapati D, Umesi U, Vyas G, Oyelakin A, Kodjo K, Ojimba C, Jegede O, Nisenoff C, Jolayemi A. On Neuropsychiatric Manifestations of Basal Ganglia Injury: A Report of Three Cases and Literature Review. Case Reports In Neurological Medicine 2019, 2019: 3298791. PMID: 31080680, PMCID: PMC6475530, DOI: 10.1155/2019/3298791.Peer-Reviewed Original ResearchBasal ganglia pathologyNeuropsychiatric manifestationsBasal gangliaBilateral basal ganglia calcificationBasal ganglia injuryTreatment-refractory psychosisBasal ganglia calcificationDiagnosis of schizophreniaRefractory psychosisVisual disturbancesClinical evidenceMotor functionPsychiatric symptomsNeurological etiologyPsychotic symptomsSymptomsAffective disturbancesSubsequent manifestationPsychotic disturbancesPathologyMotor processingPatientsGangliaManifestationsThird case
2007
Lamotrigine as Add-On Therapy in Schizophrenia
Goff DC, Keefe R, Citrome L, Davy K, Krystal JH, Large C, Thompson TR, Volavka J, Webster EL. Lamotrigine as Add-On Therapy in Schizophrenia. Journal Of Clinical Psychopharmacology 2007, 27: 582-589. PMID: 18004124, DOI: 10.1097/jcp.0b013e31815abf34.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsAntipsychotic AgentsClozapineDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug ResistanceDrug Therapy, CombinationFemaleHumansLamotrigineMaleMiddle AgedPatient CompliancePatient DropoutsPsychiatric Status Rating ScalesSchizophreniaSeverity of Illness IndexSuicide, AttemptedTreatment OutcomeTriazinesConceptsNegative Syndrome Scale total scoreScale total scoreAntipsychotic medicationTotal scoreTreatment groupsSchizophrenia patientsPlacebo-controlled trialPrimary end pointParallel-group trialUse of lamotrigineClinical Global ImpressionAtypical antipsychotic medicationsResidual psychotic symptomsSymptom total scoreNegative Symptoms total scoreLamotrigine augmentationLamotrigine trialsRefractory psychosisAtypical antipsychoticsCognitive composite scoreWeek 12Global ImpressionTreat samplePsychotic symptomsLamotrigine
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