2023
Predictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset
Karamchandani K, Khorsand S, Ebeling C, Yan L, Nakonezny P, Carr Z. Predictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset. Journal Of Surgical Research 2023, 293: 482-489. PMID: 37827025, DOI: 10.1016/j.jss.2023.09.030.Peer-Reviewed Original ResearchConceptsPostoperative respiratory failurePredictors of failureDay of surgeryRespiratory failureNoncardiac surgeryNational Surgical Quality Improvement Project databaseSurgeons National Surgical Quality Improvement Project databaseMultiple logistic regression modelACS-NSQIP datasetsPreoperative prealbumin levelRetrospective cohort studyAnesthesiologists physical statusRetrospective cohort analysisLogistic regression modelsPreoperative ascitesPreoperative creatininePostoperative complicationsPrealbumin levelsCohort studyStudy cohortDisseminated cancerCohort analysisAmerican CollegePatientsPhysical status
2022
A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure
Stavres J, Luck J, Hamaoka T, Blaha C, Cauffman A, Dalton P, Herr MD, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure. AJP Regulatory Integrative And Comparative Physiology 2022, 323: r875-r888. PMID: 36222880, PMCID: PMC9678418, DOI: 10.1152/ajpregu.00190.2022.Peer-Reviewed Original ResearchConceptsBlood pressure indexTime-tension indexMean blood pressureBlood pressureAcid-sensing ion channelsDose of amilorideHealthy adultsOral doseIsometric plantar flexion exercisesVolume-matched placeboTotal exercise durationBlood pressure responseSingle oral doseHeart rate responsePlantar flexion exerciseBFR exerciseExercise tolerancePlacebo trialMuscle painExercise durationFlexion exercisePlantar flexionHeart ratePressure indexPain
2020
Perioperative risk factors in patients with idiopathic pulmonary fibrosis: a historical cohort study
McDowell BJ, Karamchandani K, Lehman EB, Conboy MJ, Carr ZJ. Perioperative risk factors in patients with idiopathic pulmonary fibrosis: a historical cohort study. Journal Canadien D'anesthésie 2020, 68: 81-91. PMID: 33029686, DOI: 10.1007/s12630-020-01828-9.Peer-Reviewed Original ResearchConceptsAcute respiratory worseningIdiopathic pulmonary fibrosisOne-year mortalityHistorical cohort studyRisk factorsIPF patientsCohort studyPulmonary fibrosisSurgical timeSingle-center historical cohort studyHome oxygen requirementHome oxygen usePostoperative acute exacerbationAdverse postoperative outcomesPerioperative risk factorsIndependent risk factorDay of surgeryPerioperative risk stratificationMultivariable regression analysisActive pneumoniaAcute exacerbationAE-IPFPostoperative pneumoniaRespiratory worseningPerioperative factors
2019
CHA2DS2-VASc Score and In-Hospital Mortality in Critically Ill Patients With New-Onset Atrial Fibrillation
Karamchandani K, Schoaps RS, Abendroth T, Carr ZJ, King TS, Bonavia A. CHA2DS2-VASc Score and In-Hospital Mortality in Critically Ill Patients With New-Onset Atrial Fibrillation. Journal Of Cardiothoracic And Vascular Anesthesia 2019, 34: 1165-1171. PMID: 31899140, DOI: 10.1053/j.jvca.2019.11.044.Peer-Reviewed Original ResearchConceptsNew-onset atrial fibrillationIntensive care unitTertiary care academic institutionHospital mortalityVASc scoreAtrial fibrillationIll patientsAdult patientsVascular diseasePrognostic markerTertiary care academic medical centerAssociation of CHAConcomitant vascular diseaseHospital mortality rateIn-Hospital MortalitySingle-center studyReliable prognostic markersAcademic medical centerElectronic medical recordsCHA2DS2-VAScHospital deathCare unitMedical recordsRetrospective analysisMedical CenterPost‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database
Bruceta M, De Souza L, Carr ZJ, Bonavia A, Kunselman AR, Karamchandani K. Post‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database. Acta Anaesthesiologica Scandinavica 2019, 64: 319-328. PMID: 31710692, DOI: 10.1111/aas.13504.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedBody Mass IndexCohort StudiesCritical CareDatabases, FactualElective Surgical ProceduresFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedOperative TimePatient AdmissionPennsylvaniaPostoperative ComplicationsReoperationRisk FactorsSurgical Procedures, OperativeTertiary Care CentersConceptsElective non-cardiac surgeryPost-operative ICU admissionNon-cardiac surgeryIntensive care unitBody mass indexElevated body mass indexCurrent Procedural TerminologyICU admissionACS-NSQIPDisseminated cancerPost-operative intensive care unit admissionIntensive care unit admissionTertiary care academic medical centerLonger hospital lengthSurgery-specific characteristicsCare unit admissionObservational cohort studySingle-center analysisMultivariable logistic regressionICD-9 codesLonger procedure durationAcademic medical centerDisease billing codeHospital mortalityUnit admissionStroke prophylaxis in critically-ill patients with new-onset atrial fibrillation
Schoaps RS, Quintili A, Bonavia A, Carr ZJ, Lehman EB, Abendroth T, Karamchandani K. Stroke prophylaxis in critically-ill patients with new-onset atrial fibrillation. Journal Of Thrombosis And Thrombolysis 2019, 48: 394-399. PMID: 30963394, DOI: 10.1007/s11239-019-01854-5.Peer-Reviewed Original ResearchConceptsNew-onset atrial fibrillationCHA2DS2-VASc scoreOral anticoagulant therapyOral anticoagulantsIll patientsStroke prophylaxisAnticoagulant therapyHospital dischargeAtrial fibrillationEffective stroke prophylaxisOnset atrial fibrillationStroke/TIACongestive heart failureLong-term incidenceElectronic medical recordsEligible patientsICU survivorsAdult patientsHeart failureThromboembolic diseaseMedical recordsHigh incidencePatientsAnticoagulantsStudy period
2018
Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis
Carr ZJ, Van De Louw A, Fehr G, Li JD, Kunselman A, Ruiz-Velasco V. Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis. BMC Research Notes 2018, 11: 41. PMID: 29338778, PMCID: PMC5771199, DOI: 10.1186/s13104-018-3165-4.Peer-Reviewed Original ResearchConceptsRNA expressionIntensive care unit admissionBlood white cell countCare unit admissionOdds of mortalityDiagnosis of sepsisBody mass indexIntensive care unitWhite cell countGPR43 expressionUnit admissionOne-unit increaseCare unitMass indexSignificant morbidityQuantitative real-time PCRGPR43 receptorInflammatory responseImmunomodulatory pathwaysReceptor 43Receptor expressionReal-time PCRSepsisCell countPatients
2012
Does Every Code Need a “Reader?” Improvement of Rare Event Management With a Cognitive Aid “Reader” During a Simulated Emergency
Burden AR, Carr ZJ, Staman GW, Littman JJ, Torjman MC. Does Every Code Need a “Reader?” Improvement of Rare Event Management With a Cognitive Aid “Reader” During a Simulated Emergency. Simulation In Healthcare The Journal Of The Society For Simulation In Healthcare 2012, 7: 1-9. PMID: 22113440, DOI: 10.1097/sih.0b013e31822c0f20.Peer-Reviewed Original ResearchMeSH KeywordsAdultCritical CareEmergency Service, HospitalEvidence-Based MedicineFemaleHeart ArrestHospital Rapid Response TeamHumansInternship and ResidencyMaleMalignant HyperthermiaMedical ErrorsObstetricsPatient SimulationPilot ProjectsPregnancyPregnancy ComplicationsQuality of Health CareReadingVideo RecordingConceptsMalignant hyperthermiaPercent of subjectsCritical care nursesDantrolene dosePrompt treatmentPatient survivalCardiac arrestCare nursesObstetric traineesTreatment decisionsPhysiologic variablesCritical treatment stepsResuscitation cartResident physiciansCognitive aidsSubjectsAnesthesiologyCA useMedical studentsCritical actionsPercentPrior lectureAnesthesiologistsSimulated emergencyNurses