2018
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice
Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C, LaMotte RH. Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. Neuroscience Letters 2018, 668: 154-158. PMID: 29355697, PMCID: PMC5829013, DOI: 10.1016/j.neulet.2018.01.031.Peer-Reviewed Original ResearchConceptsDorsal root gangliaBehavioral hypersensitivityNeuronal hyperexcitabilityRoot gangliaCompressed dorsal root ganglionNormal nociceptive responsesAnti-nociceptive effectsChronic neuropathic painPostoperative pain managementCentral nervous systemIntact DRGsL4 DRGChronic compressionIpsilateral pawNeuropathic painRadicular painHind pawsPain managementIpsilateral hindNociceptive informationNociceptive responsesPain behaviorIntervertebral foramenNociceptive stimuliLocal anesthetics
2017
Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis
Qu L, Fu K, Shimada SG, LaMotte RH. Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis. Journal Of Neurophysiology 2017, 118: 619-624. PMID: 28446581, PMCID: PMC5511864, DOI: 10.1152/jn.00187.2017.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSquaric acid dibutylesterAllergic itchNeuronal activationContact hypersensitivityContact dermatitisMurine modelItch-related scratching behaviorBehavioral effectsDorsal root ganglion neuronsItch-like behaviorsPrimary sensory neuronsWhole-cell recordingsPromising therapeutic targetPersistent itchItch responseIonic mechanismsGanglion neuronsScratching behaviorChannel blockersCXCL10Sensory neuronsTherapeutic targetChannel inhibitorsCell recordings
2015
Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLOS ONE 2015, 10: e0137512. PMID: 26356638, PMCID: PMC4565551, DOI: 10.1371/journal.pone.0137512.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsChronic DiseaseGanglia, SpinalHyperalgesiaMaleMice, Inbred C57BLNerve Compression SyndromesNociceptorsPainConceptsDorsal root gangliaPunctate mechanical stimuliSpontaneous activityChronic compressionCutaneous nociceptorsL3 dorsal root gangliaPost-operative day 2Evoked pain behaviorsPain-like behaviorsVon Frey filamentsDorsum of footUnoperated control miceMechanical stimuliCutaneous C nociceptorsBehavioral hyperalgesiaCCD surgeryIntraforaminal stenosisMechanical allodyniaRadicular painC-nociceptorsDRG neuronsPain behaviorControl miceEnhanced excitabilityControl neuronsCXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis
Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. Pain 2015, 156: 1737-1746. PMID: 25932692, PMCID: PMC4545682, DOI: 10.1097/j.pain.0000000000000208.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPain-like behaviorsContact hypersensitivityAllergic itchChemokine CXCL10Contact dermatitisCutaneous dorsal root ganglion neuronsPathophysiology of ACDExperimental allergic contact dermatitisDorsal root ganglion neuronsSquaric acid dibutylesterDorsal root gangliaSignificant health burdenUpregulation of CXCL10Chemokine receptor signalingCXCR3 mRNAPersistent itchSpontaneous itchInflammatory painCommon symptomsControl miceReceptor CXCR3Skin inflammationGanglion neuronsRoot ganglia
2014
Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain 2014, 137: 1039-1050. PMID: 24549959, PMCID: PMC3959553, DOI: 10.1093/brain/awu007.Peer-Reviewed Original ResearchConceptsContact hypersensitivityPruriceptive neuronsEnhanced excitabilityNervous systemNociceptive dorsal root ganglion (DRG) neuronsSodium currentVehicle-treated control animalsDorsal root ganglion neuronsSquaric acid dibutyl esterItch-like behaviorsPain-related behaviorsResistant sodium currentsAllergic contact dermatitisAction potential activityWhole-cell recordingsInflammatory itchPersistent itchPruritic disordersSpontaneous itchSpontaneous scratchingAcute itchNeuronal hyperexcitabilityNociceptive neuronsPruritic diseasesCommon symptoms
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation Channels
2011
In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans
Ma C, Nie H, Gu Q, Sikand P, LaMotte RH. In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans. Journal Of Neurophysiology 2011, 107: 357-363. PMID: 21994268, PMCID: PMC3349700, DOI: 10.1152/jn.00801.2011.Peer-Reviewed Original ResearchConceptsNociceptive sensationsCowhage spiculesC-nociceptorsNociceptive neuronsReceptive fieldsCutaneous receptive fieldsNoxious mechanical stimuliC-fibre rangePeripheral neural mechanismsExtracellular electrophysiological recordingsAxonal conduction velocityMean discharge rateChemical itchElicit itchChemical stimuliMechanosensitive nociceptorsConduction velocityMechanosensitive neuronsHeat stimuliItchCell bodiesElectrophysiological recordingsVivo responseCapsaicinHistamine