2024
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte R. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. 2024, 23-32. DOI: 10.1007/978-981-99-8921-8_2.Peer-Reviewed Original ResearchSquaric acid dibutyl esterAllergic contact dermatitisPersistent itchingPathogenesis of allergic contact dermatitisPain-like behaviorsMechanically evoked itchMechanisms of itchPeripheral neural mechanismsClinically significant problemReceptor CXCR3Excitatory responsesIP-10Chemokine CXCL10In vivo recordingsCutaneous sitesLocal inflammationSpontaneous activityPruritic disordersAnimal modelsPainTopical applicationItchingItch disordersMiceTherapeutic targetItch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice
Malewicz-Oeck N, Zhang Z, Shimada S, LaMotte R. Itch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice. International Journal Of Molecular Sciences 2024, 25: 7718. PMID: 39062959, PMCID: PMC11276812, DOI: 10.3390/ijms25147718.Peer-Reviewed Original ResearchIrritant contact dermatitisDay 1Heat stimuliSkin inflammationSigns of spontaneous painContact dermatitisHyperalgesia-like behaviorResponses to pruritogensPain-like behaviorsSodium lauryl sulfateCompared to salineMeasurement of skin thicknessSpontaneous painIncreased skin thicknessHistamine-dependentPain behaviorCutaneous inflammationScratching boutsMouse modelPainSkin thicknessItchingInflammationMiceDay 0
2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
2008
Behavioral differentiation between itch and pain in mouse
Shimada SG, LaMotte RH. Behavioral differentiation between itch and pain in mouse. Pain 2008, 139: 681-687. PMID: 18789837, PMCID: PMC2723192, DOI: 10.1016/j.pain.2008.08.002.Peer-Reviewed Original Research