2022
A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure
Stavres J, Luck J, Hamaoka T, Blaha C, Cauffman A, Dalton P, Herr MD, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure. AJP Regulatory Integrative And Comparative Physiology 2022, 323: r875-r888. PMID: 36222880, PMCID: PMC9678418, DOI: 10.1152/ajpregu.00190.2022.Peer-Reviewed Original ResearchConceptsBlood pressure indexTime-tension indexMean blood pressureBlood pressureAcid-sensing ion channelsDose of amilorideHealthy adultsOral doseIsometric plantar flexion exercisesVolume-matched placeboTotal exercise durationBlood pressure responseSingle oral doseHeart rate responsePlantar flexion exerciseBFR exerciseExercise tolerancePlacebo trialMuscle painExercise durationFlexion exercisePlantar flexionHeart ratePressure indexPain
2019
Post‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database
Bruceta M, De Souza L, Carr ZJ, Bonavia A, Kunselman AR, Karamchandani K. Post‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database. Acta Anaesthesiologica Scandinavica 2019, 64: 319-328. PMID: 31710692, DOI: 10.1111/aas.13504.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedBody Mass IndexCohort StudiesCritical CareDatabases, FactualElective Surgical ProceduresFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedOperative TimePatient AdmissionPennsylvaniaPostoperative ComplicationsReoperationRisk FactorsSurgical Procedures, OperativeTertiary Care CentersConceptsElective non-cardiac surgeryPost-operative ICU admissionNon-cardiac surgeryIntensive care unitBody mass indexElevated body mass indexCurrent Procedural TerminologyICU admissionACS-NSQIPDisseminated cancerPost-operative intensive care unit admissionIntensive care unit admissionTertiary care academic medical centerLonger hospital lengthSurgery-specific characteristicsCare unit admissionObservational cohort studySingle-center analysisMultivariable logistic regressionICD-9 codesLonger procedure durationAcademic medical centerDisease billing codeHospital mortalityUnit admissionIn a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task
Carr ZJ, Miller L, Ruiz-Velasco V, Kunselman AR, Karamchandani K. In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task. Journal Of Neuroimmune Pharmacology 2019, 14: 383-390. PMID: 31119596, DOI: 10.1007/s11481-019-09857-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsAppetitive BehaviorAttentionDeliriumDisease Models, AnimalDrug Evaluation, PreclinicalExecutive FunctionFemaleFrontal LobeHydrocortisoneInflammationLipopolysaccharidesQuetiapine FumarateRandom AllocationRatsRats, Sprague-DawleyReversal LearningRewardSet, PsychologyTumor Necrosis Factor-alphaConceptsCortisol levelsTumor necrosis factor-alpha levelsNecrosis factor-alpha levelsSprague-Dawley female ratsBeneficial effectsModel of neuroinflammationTreatment of deliriumTNF-α levelsAtypical antipsychotic medicationsEffects of quetiapineDawley female ratsIntraperitoneal placeboPlacebo groupQuetiapine groupNeuroinflammatory modelReversal learningAntipsychotic medicationPre-clinical validationCortisol secretionSerum cortisolFemale ratsPlaceboCortisol productionRodent modelsQuetiapineStroke prophylaxis in critically-ill patients with new-onset atrial fibrillation
Schoaps RS, Quintili A, Bonavia A, Carr ZJ, Lehman EB, Abendroth T, Karamchandani K. Stroke prophylaxis in critically-ill patients with new-onset atrial fibrillation. Journal Of Thrombosis And Thrombolysis 2019, 48: 394-399. PMID: 30963394, DOI: 10.1007/s11239-019-01854-5.Peer-Reviewed Original ResearchConceptsNew-onset atrial fibrillationCHA2DS2-VASc scoreOral anticoagulant therapyOral anticoagulantsIll patientsStroke prophylaxisAnticoagulant therapyHospital dischargeAtrial fibrillationEffective stroke prophylaxisOnset atrial fibrillationStroke/TIACongestive heart failureLong-term incidenceElectronic medical recordsEligible patientsICU survivorsAdult patientsHeart failureThromboembolic diseaseMedical recordsHigh incidencePatientsAnticoagulantsStudy period
2018
A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea
Carr ZJ, Vells B, Wood BR, Lowery JD, Rogers AM, Kunselman AA, Karamchandani K, Vaida SJ. A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea. Medicine 2018, 97: e12585. PMID: 30278569, PMCID: PMC6181597, DOI: 10.1097/md.0000000000012585.Peer-Reviewed Original ResearchMeSH KeywordsAgedAirway ExtubationAnesthesia Recovery PeriodAnesthesia, GeneralBenzhydryl CompoundsBlood PressureDouble-Blind MethodFemaleHumansLength of StayMaleMiddle AgedModafinilPilot ProjectsPreoperative PeriodProof of Concept StudyRespiratory RateSleep Apnea, ObstructiveWakefulness-Promoting AgentsConceptsObstructive sleep apneaGeneral anesthesiaFunctional recoverySleep apneaPrimary outcomePACU lengthPsychomotor stimulantsPost-anesthesia care unit lengthDiagnosis of OSAIntraoperative bispectral index valuePlacebo-controlled pilot studyPost-anesthesia care unitPilot studyPostoperative pain scoresPost-anesthesia recoveryBispectral index valuesModafinil groupPain scoresSurgical populationNarcotic consumptionArterial pressureDaytime somnolenceCare unitAnesthesiaVolatile anestheticsIncreased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis
Carr ZJ, Van De Louw A, Fehr G, Li JD, Kunselman A, Ruiz-Velasco V. Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis. BMC Research Notes 2018, 11: 41. PMID: 29338778, PMCID: PMC5771199, DOI: 10.1186/s13104-018-3165-4.Peer-Reviewed Original ResearchConceptsRNA expressionIntensive care unit admissionBlood white cell countCare unit admissionOdds of mortalityDiagnosis of sepsisBody mass indexIntensive care unitWhite cell countGPR43 expressionUnit admissionOne-unit increaseCare unitMass indexSignificant morbidityQuantitative real-time PCRGPR43 receptorInflammatory responseImmunomodulatory pathwaysReceptor 43Receptor expressionReal-time PCRSepsisCell countPatients
2012
Does Every Code Need a “Reader?” Improvement of Rare Event Management With a Cognitive Aid “Reader” During a Simulated Emergency
Burden AR, Carr ZJ, Staman GW, Littman JJ, Torjman MC. Does Every Code Need a “Reader?” Improvement of Rare Event Management With a Cognitive Aid “Reader” During a Simulated Emergency. Simulation In Healthcare The Journal Of The Society For Simulation In Healthcare 2012, 7: 1-9. PMID: 22113440, DOI: 10.1097/sih.0b013e31822c0f20.Peer-Reviewed Original ResearchMeSH KeywordsAdultCritical CareEmergency Service, HospitalEvidence-Based MedicineFemaleHeart ArrestHospital Rapid Response TeamHumansInternship and ResidencyMaleMalignant HyperthermiaMedical ErrorsObstetricsPatient SimulationPilot ProjectsPregnancyPregnancy ComplicationsQuality of Health CareReadingVideo RecordingConceptsMalignant hyperthermiaPercent of subjectsCritical care nursesDantrolene dosePrompt treatmentPatient survivalCardiac arrestCare nursesObstetric traineesTreatment decisionsPhysiologic variablesCritical treatment stepsResuscitation cartResident physiciansCognitive aidsSubjectsAnesthesiologyCA useMedical studentsCritical actionsPercentPrior lectureAnesthesiologistsSimulated emergencyNurses