2019
In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task
Carr ZJ, Miller L, Ruiz-Velasco V, Kunselman AR, Karamchandani K. In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task. Journal Of Neuroimmune Pharmacology 2019, 14: 383-390. PMID: 31119596, DOI: 10.1007/s11481-019-09857-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsAppetitive BehaviorAttentionDeliriumDisease Models, AnimalDrug Evaluation, PreclinicalExecutive FunctionFemaleFrontal LobeHydrocortisoneInflammationLipopolysaccharidesQuetiapine FumarateRandom AllocationRatsRats, Sprague-DawleyReversal LearningRewardSet, PsychologyTumor Necrosis Factor-alphaConceptsCortisol levelsTumor necrosis factor-alpha levelsNecrosis factor-alpha levelsSprague-Dawley female ratsBeneficial effectsModel of neuroinflammationTreatment of deliriumTNF-α levelsAtypical antipsychotic medicationsEffects of quetiapineDawley female ratsIntraperitoneal placeboPlacebo groupQuetiapine groupNeuroinflammatory modelReversal learningAntipsychotic medicationPre-clinical validationCortisol secretionSerum cortisolFemale ratsPlaceboCortisol productionRodent modelsQuetiapine
2018
Gender differences in the use of atypical antipsychotic medications for ICU delirium
Karamchandani K, Schoaps RS, Printz J, Kowaleski JM, Carr ZJ. Gender differences in the use of atypical antipsychotic medications for ICU delirium. Critical Care 2018, 22: 220. PMID: 30236134, PMCID: PMC6148964, DOI: 10.1186/s13054-018-2143-5.Peer-Reviewed Original ResearchDoes Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature
Carr ZJ, Cios TJ, Potter KF, Swick JT. Does Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature. Current Neurology And Neuroscience Reports 2018, 18: 64. PMID: 30083844, DOI: 10.1007/s11910-018-0873-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAgedAnimalsCognitive DysfunctionDeliriumDexmedetomidineHumansPostoperative ComplicationsConceptsUse of dexmedetomidinePostoperative deliriumCognitive dysfunctionAcute postoperative deliriumPostoperative cognitive dysfunctionAlpha-2 agonistsIncidence of POCDAnti-inflammatory propertiesHigh patient mortalityHospital lengthElderly patientsHeart failurePostsurgical patientsPatient mortalityImmunomodulatory effectsVascular diseaseBrain injuryFavorable outcomeClinical studiesDexmedetomidineHigh prevalenceHuman trialsClinical investigationRecent FindingsThereAnimal models