2008
Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea.
Akhtar S, Podgoreanu M, Harrison B, Brull S. Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea. Minerva Anestesiologica 2008, 74: 643-50. PMID: 18971893.Peer-Reviewed Original ResearchConceptsEffects of lidocaineEndothelin-1Extracellular calciumRat tracheaAirway smooth muscle constrictionET-1-induced constrictionET-1-induced contractionAirway smooth muscle contractionCarbachol concentration-response curveDirect relaxant effectIntracellular calcium entryET-1 responseSmooth muscle constrictionNM ET-1Concentration-response curvesG-protein-coupled endothelin receptorsSmooth muscle contractionUnpaired t-testASM contractionContractile responseMaximal contractilityRelaxant effectASM relaxationEndothelin receptorsMuscle constriction
1999
Differential bronchodilatory effects of terbutaline, diltiazem, and aminophylline in canine intraparenchymal airways
Akhtar S, Mazzeo A, Cheng E, Bosnjak Z, Kampine J. Differential bronchodilatory effects of terbutaline, diltiazem, and aminophylline in canine intraparenchymal airways. Critical Care Medicine 1999, 27: 1551-1556.. PMID: 10470763, DOI: 10.1097/00003246-199908000-00024.Peer-Reviewed Original ResearchConceptsIntraparenchymal airwaysVolatile anestheticsAdministration of terbutalineAnimal research laboratoryDose-response curveAirway ringsDistal airwaysTissue bathAdult dogsIsometric tensionMaximum doseAirwayBronchodilatorsAminophyllineTerbutalineAnestheticsEffective concentrationMaximum responseDogsTopographic locationFlow regulationBronchiolusBronchusAcetylcholineGreater degree