Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea.
Akhtar S, Podgoreanu M, Harrison B, Brull S. Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea. Minerva Anestesiologica 2008, 74: 643-50. PMID: 18971893.Peer-Reviewed Original ResearchConceptsEffects of lidocaineEndothelin-1Extracellular calciumRat tracheaAirway smooth muscle constrictionET-1-induced constrictionET-1-induced contractionAirway smooth muscle contractionCarbachol concentration-response curveDirect relaxant effectIntracellular calcium entryET-1 responseSmooth muscle constrictionNM ET-1Concentration-response curvesG-protein-coupled endothelin receptorsSmooth muscle contractionUnpaired t-testASM contractionContractile responseMaximal contractilityRelaxant effectASM relaxationEndothelin receptorsMuscle constriction