2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation Channels
1999
Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia
Song X, Hu S, Greenquist K, Zhang J, LaMotte R. Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia. Journal Of Neurophysiology 1999, 82: 3347-3358. PMID: 10601466, DOI: 10.1152/jn.1999.82.6.3347.Peer-Reviewed Original ResearchConceptsDorsal root gangliaChronic compressionAcute injuryRoot gangliaPreoperative valuesPostoperative testingFoot withdrawalSpontaneous dischargeIntact sympathetic nervous systemUnmyelinated peripheral nerve fibersEctopic neuronal dischargesEctopic spontaneous dischargesSympathetic nervous systemLow back painPeripheral nerve fibersDorsal root fibersBlood-borne chemicalsExtracellular electrophysiological recordingsActive myelinated fibersCotton wispNonsurgical ratsMechanical hyperalgesiaEctopic dischargesThermal hyperalgesiaBack pain
1991
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
Baumann T, Simone D, Shain C, LaMotte R. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. Journal Of Neurophysiology 1991, 66: 212-227. PMID: 1919668, DOI: 10.1152/jn.1991.66.1.212.Peer-Reviewed Original ResearchConceptsAfferent fibersNeurogenic hyperalgesiaPrimary hyperalgesiaNociceptive fibersPrimary afferentsIntradermal injectionHeat stimuliInjection siteReceptive fieldsCutaneous primary afferent fibersCapsaicin injection siteCutaneous afferent fibersNociceptive afferent fibersInjection of capsaicinCapsaicin-induced painPrimary afferent fibersPeripheral nervous systemPeripheral neural mechanismsArea of skinCapsaicin painSecondary hyperalgesiaDepressed responsivenessCapsaicin injectionIntense painHyperalgesiaNeurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons
Simone D, Sorkin L, Oh U, Chung J, Owens C, LaMotte R, Willis W. Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. Journal Of Neurophysiology 1991, 66: 228-246. PMID: 1919669, DOI: 10.1152/jn.1991.66.1.228.Peer-Reviewed Original ResearchConceptsSpinothalamic tract neuronsSTT neuronsWDR neuronsInjection siteHT neuronsNeurogenic hyperalgesiaTract neuronsIntradermal injectionPunctate stimuliCapsaicin injection siteMicrograms of capsaicinInjection of capsaicinCutaneous mechanical stimulationInjection of vehicleCentral neural correlatesSuprathreshold heat stimuliCutaneous hyperalgesiaWDR cellsCapsaicin injectionHeat painHyperalgesiaPainAnesthetized monkeysPreinjection valuesHeat stimuli
1990
A model of peripheral mononeuropathy in the rat
Hirata H, Pataky A, Kajander K, LaMotte R, Collins J. A model of peripheral mononeuropathy in the rat. Pain 1990, 42: 253-254. PMID: 2174143, DOI: 10.1016/0304-3959(90)91169-j.Peer-Reviewed Original Research
1987
Hyperalgesia to heat after intradermal injection of capsaicin
Simone D, Ngeow J, Putterman G, LaMotte R. Hyperalgesia to heat after intradermal injection of capsaicin. Brain Research 1987, 418: 201-203. PMID: 3664271, DOI: 10.1016/0006-8993(87)90982-6.Peer-Reviewed Original Research
1984
Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human
LaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human. Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.Peer-Reviewed Original ResearchConceptsNociceptive afferent fibersDevelopment of hyperalgesiaConditioning stimulusPain ratingsHeat stimulationAfferent fibersHairy skinHeat-evoked dischargesCervical spinal cordMagnitude of painMild heat injurySimilar response magnitudesMean frequencyPoststimulus time histogramsNociceptor activityCutaneous painResponse latencyHyperalgesic skinSpinal cordAwake humansC-fibersAnesthetized monkeysConduction velocityPainHeat stimuliPeripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers
Torebjörk H, LaMotte R, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers. Journal Of Neurophysiology 1984, 51: 325-339. PMID: 6707724, DOI: 10.1152/jn.1984.51.2.325.Peer-Reviewed Original ResearchConceptsConditioning stimulusIntensity-response functionsNormal skinMost subjectsC-mechanoheat nociceptorsPeripheral neural correlateHeat pain sensationMild heat injuryMagnitude ratingsReceptive fieldsHeat injurySupra-threshold stimuliShort-duration stimuliPain thresholdCutaneous painHeat painPain sensationC-fibersPainNociceptorsHairy skinUninjured skinHeat stimulationMagnitude of responseNeuronal correlates
1983
Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humans
Robinson C, Torebjörk H, LaMotte R. Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humans. Brain Research 1983, 274: 87-106. PMID: 6616259, DOI: 10.1016/0006-8993(83)90523-1.Peer-Reviewed Original ResearchConceptsMagnitude of painThermal stimuliContact thermal stimulatorMost nociceptorsNociceptive afferentsPeroneal nerveNociceptor responsesPain magnitudePain ratingsPain sensitivityPain sensationUnmyelinated fibersPainNormal skinMild burnsPsychophysical detectionDegrees CNeural responsesNociceptorsAfferentsThermal stimulatorCapacity of humansIncrement detectionDegrees C.Detection thresholdLatency to detection of first pain
Campbell J, LaMotte R. Latency to detection of first pain. Brain Research 1983, 266: 203-208. PMID: 6871657, DOI: 10.1016/0006-8993(83)90650-9.Peer-Reviewed Original ResearchConceptsFirst painFirst sensationShort-latency responsesQuality of sensationDistal forearmPrimary afferentsPain sensationConduction velocityThenar eminenceGlabrous handHeat stimuliPainLatency responsesMedian response latencyShort latencyDistal armSensationResponse latencyStimuliSubjectsLatencyAfferentsArmForearmMs
1982
Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat
LaMotte R, Thalhammer J, Torebjörk H, Robinson C. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. Journal Of Neuroscience 1982, 2: 765-781. PMID: 7086482, PMCID: PMC6564351, DOI: 10.1523/jneurosci.02-06-00765.1982.Peer-Reviewed Original ResearchConceptsConditioning stimulusCutaneous hyperalgesiaMild injuryDevelopment of hyperalgesiaHeat injuryMagnitude of hyperalgesiaMild heat injurySingle conditioning stimulusMagnitude of sensitizationPeripheral neural mechanismsReceptive fieldsPeroneal nervePeripheral determinantsCutaneous receptorsC-fibersAwake humansConduction blockAnesthetized monkeysHyperalgesiaNociceptorsPainGlabrous skinNormal skinInjuryHeat stimulationSpatial properties of nociceptor sensitization following heat injury of the skin
Thalhammer J, LaMotte R. Spatial properties of nociceptor sensitization following heat injury of the skin. Brain Research 1982, 231: 257-265. PMID: 7055680, DOI: 10.1016/0006-8993(82)90364-x.Peer-Reviewed Original Research