2017
Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis
Qu L, Fu K, Shimada SG, LaMotte RH. Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis. Journal Of Neurophysiology 2017, 118: 619-624. PMID: 28446581, PMCID: PMC5511864, DOI: 10.1152/jn.00187.2017.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSquaric acid dibutylesterAllergic itchNeuronal activationContact hypersensitivityContact dermatitisMurine modelItch-related scratching behaviorBehavioral effectsDorsal root ganglion neuronsItch-like behaviorsPrimary sensory neuronsWhole-cell recordingsPromising therapeutic targetPersistent itchItch responseIonic mechanismsGanglion neuronsScratching behaviorChannel blockersCXCL10Sensory neuronsTherapeutic targetChannel inhibitorsCell recordings
1996
Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction
Petersen M, Zhang J, Zhang J, LaMotte R. Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction. Pain 1996, 67: 391-397. PMID: 8951934, DOI: 10.1016/0304-3959(96)03146-6.Peer-Reviewed Original ResearchConceptsDorsal root ganglion cellsUninjured nerveGanglion cellsSpontaneous activityWhole-cell patch-clamp recordingsAbnormal spontaneous activityChronic nerve constrictionPeripheral nerve injuryPrimary sensory neuronsPatch-clamp recordingsMedium-sized cellsNerve constrictionTight ligationNerve injuryDRG cellsSciatic nerveNormal nervesAdult ratsSensory neuronsNerveNorepinephrineLow dosesAction potentialsCultures 11Current clampChapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat
LaMotte R, Zhang J, Petersen M. Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat. Progress In Brain Research 1996, 110: 105-111. PMID: 9000719, DOI: 10.1016/s0079-6123(08)62568-6.Peer-Reviewed Original ResearchConceptsDorsal root gangliaSensory neuronsIntact neuronsPartial peripheral nerve injuryDorsal root ganglion cellsChronic nerve constrictionPeripheral axonal injuryPeripheral nerve injuryPeripheral sensory neuronsPrimary sensory neuronsNerve constrictionNerve injuryAbnormal responsivenessAxonal injuryCollateral sproutingNeuropathological changesNociceptive activityDRG cellsRoot gangliaGanglion cellsSame nerveInjury siteUnmyelinated axonsAxonsNeurons
1992
Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis
LaMotte R. Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis. Journal Of Pain 1992, 1: 115-126. DOI: 10.1016/1058-9139(92)90040-j.Peer-Reviewed Original ResearchSpinothalamic tract cellsDorsal hornTract cellsNociceptive primary afferent neuronsPrimary afferent neuronsPrimary sensory neuronsCentral nervous systemNon-neuronal tissuesAfferent neuronsCutaneous mechanoreceptive afferentsPrimary afferentsConvergent inputsDifferent populationsPeripheral tissuesSensory neuronsPainCutaneous injuryNervous systemMechanoreceptive afferentsNoxious eventsProlonged enhancementNeuronsItchAllodyniaAlloknesis