2015
CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis
Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. Pain 2015, 156: 1737-1746. PMID: 25932692, PMCID: PMC4545682, DOI: 10.1097/j.pain.0000000000000208.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPain-like behaviorsContact hypersensitivityAllergic itchChemokine CXCL10Contact dermatitisCutaneous dorsal root ganglion neuronsPathophysiology of ACDExperimental allergic contact dermatitisDorsal root ganglion neuronsSquaric acid dibutylesterDorsal root gangliaSignificant health burdenUpregulation of CXCL10Chemokine receptor signalingCXCR3 mRNAPersistent itchSpontaneous itchInflammatory painCommon symptomsControl miceReceptor CXCR3Skin inflammationGanglion neuronsRoot ganglia
1996
Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers
Lundell J, Silverman D, Brull S, O'Connor T, Kitahata L, Collins J, LaMotte R. Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers. Anesthesiology 1996, 84: 502-509. PMID: 8659776, DOI: 10.1097/00000542-199603000-00003.Peer-Reviewed Original ResearchConceptsHealthy volunteersEffect of pretreatmentNonsteroidal antiinflammatory drugsSystemic side effectsBradykinin-induced hyperalgesiaContact thermal stimulatorRepeated-measures analysisInflammatory painBradykinin injectionPain intensityPain thresholdAntiinflammatory drugsLocal injectionHyperalgesiaSide effectsKetorolacDrug AdministrationPainMild burnsThermal stimuliThermal stimulatorInjurySelective effectInjectionSaline