Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLOS ONE 2015, 10: e0137512. PMID: 26356638, PMCID: PMC4565551, DOI: 10.1371/journal.pone.0137512.Peer-Reviewed Original ResearchConceptsDorsal root gangliaPunctate mechanical stimuliSpontaneous activityChronic compressionCutaneous nociceptorsL3 dorsal root gangliaPost-operative day 2Evoked pain behaviorsPain-like behaviorsVon Frey filamentsDorsum of footUnoperated control miceMechanical stimuliCutaneous C nociceptorsBehavioral hyperalgesiaCCD surgeryIntraforaminal stenosisMechanical allodyniaRadicular painC-nociceptorsDRG neuronsPain behaviorControl miceEnhanced excitabilityControl neurons