Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuli